Condition

Postpartum Depression (PPD) clinical trials and research

• 23Clinical trials
• 3New in 30 days
• 12Countries

Newest Postpartum Depression (PPD) clinical trials

All recruiting trials (23)

• Restoring Emotional Balance With Ketones for Women After Birth

  This study tests whether taking a ketone supplement plus group cognitive-behavioral counseling and guided exercise can help women within 12 months after birth who have postpartum depression feel better.

  Recruiting Ohio State University · Columbus, Ohio · NCT07919392

• Web-based program to help new mothers with postpartum depression

  A web-based treatment with therapist support is being tested to see if it helps women 1–12 months after giving birth who have postpartum depression.

  Recruiting Early Phase 1 Babes-Bolyai University · Cluj-Napoca, Cluj · NCT07902141

• Methyl-Donor Rich Diet in the Postpartum Period

  Researchers will test whether a methyl-donor‑rich diet in the first weeks after birth helps reduce maternal depression and supports breastfeeding and infant growth.

  Recruiting Istanbul University - Cerrahpasa · Bursa, Orhaneli̇ · NCT07887178

• Brexanolone therapy for moms with postpartum depression

  This trial tests LPCN 1154A against placebo to see if it can help reduce depression symptoms in women with severe postpartum depression.

  Recruiting at 16 sites Phase 3 Lipocine Inc. · Tucson, Arizona and 15 other locations · NCT07822321

• Two-Door Doulas: Enhanced vs Standard Medicaid Doula Care in Pregnancy

  This trial tests whether an enhanced, earlier, and more frequent doula support program helps pregnant people on Medicaid feel less depression and anxiety after birth compared with the standard Medicaid doula care in Florida.

  Recruiting University of Florida · Gainesville, Florida · NCT07799805

• Doula-delivered postpartum support with nurse coordination for people with preterm births in the NICU

  This trial tests whether doula-delivered postpartum help, guided by nurses, improves health outcomes and experiences for people with babies under 34 weeks in the NICU, compared to standard postpartum care.

  Recruiting University of South Carolina · Columbia, South Carolina · NCT07787845

• Treating peripartum depression with repetitive transcranial magnetic stimulation

  This study tests whether active rTMS can reduce depressive symptoms in pregnant people or those within a year after birth who have peripartum depression.

  Recruiting at 2 sites Psychiatric University Hospital, Zurich · Zurich and 1 other locations · NCT07774559

• Morning bright light therapy for postpartum depression

  This study tests a wearable morning bright light device to see if it’s feasible and acceptable for people within six months after giving birth who have depressive symptoms.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT07766161

• MI078 for Postpartum Depression: a new option for new mothers

  A new drug, MI078, is being tested to see if it helps treating postpartum depression in women who recently gave birth.

  Recruiting at 36 sites Phase 3 Nanjing Minova Pharmaceutical Co., Ltd. · Hefei, Anhui and 35 other locations · NCT07721961

• Parents and Babies: a virtual and hybrid program to support perinatal mood for LGBTQ+ parents

  A pilot program tests a Parents and Babies intervention to see if it’s feasible, acceptable, and potentially helpful for LGBTQ+ people who are pregnant or within a year postpartum and have mild depressive symptoms.

  Recruiting Northwestern University · Chicago, Illinois · NCT07607613

• Postpartum mood and alcohol use: a CM-PST approach for new mothers

  This study tests whether a six-week CM-PST program helps reduce depressive symptoms and alcohol use in new mothers within the first year after birth.

  Recruiting University of Illinois Chicago · Chicago, Illinois · NCT07485036

• iCARE online therapy for postpartum depression

  This tests whether iCARE, an online program combining cognitive behavioral and acceptance-based techniques, helps women within six months after childbirth who have postpartum depression.

  Recruiting University of Southern Denmark · Odense · NCT07384273

• Does getting the labor pain relief you expect change postpartum depression risk?

  We will see if women whose expectations about labor pain relief are met during a planned vaginal birth are less likely to have postpartum depression.

  Recruiting University of Padova · Padova, Veneto · NCT07292649

• Story-based nursing support to reduce anxiety and boost breastfeeding confidence after cesarean

  This program tests whether four short, nurse-led storytelling conversations can lower anxiety and boost breastfeeding confidence in mothers having planned or non-emergency cesarean sections.

  Recruiting Xiamen University · Nanchong, Sichuan · NCT07272252

• Voice app to help NICU mothers connect with their babies (NURTURE)

  This trial will test whether the VoiceLove mobile app helps mothers with infants in the NICU have less postpartum depression compared with usual care.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT07214597

• SAINT for postpartum depression

  This project will test whether SAINT, a fast-acting form of noninvasive brain stimulation, can quickly reduce depression symptoms in women within 12 months after giving birth whose symptoms have not improved with usual care.

  Recruiting at 4 sites Magnus Medical · Worcester, Massachusetts and 3 other locations · NCT07210255

• Home test to predict postpartum depression

  This project will test whether the Enlighten blood or saliva test taken in late pregnancy can predict which pregnant women (age 18+, singleton pregnancies enrolled before 30 weeks) will develop postpartum depression in the first three months after birth.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT07186309

• Essential Coaching Postpartum: a 6-week parent-focused text messaging program in Nova Scotia

  This study will test if a 6-week series of supportive, tailored text messages helps first-time birthing and non-birthing parents in Nova Scotia feel more confident and less anxious after their baby is born.

  Recruiting IWK Health Centre · Halifax, Nova Scotia · NCT06996067

• IV iron vs oral iron after cesarean for anemia and postpartum depression

  This study tests whether intravenous iron is better than oral iron at reducing postpartum depression in women who have moderate iron deficiency anemia after cesarean delivery.

  Recruiting Phase 4 Assistance Publique - Hôpitaux de Paris · Paris · NCT06833788

• Blood test to predict postpartum depression in pregnant women

  This study is testing a blood test to see if it can predict postpartum depression in pregnant women during their third trimester.

  Recruiting at 2 sites University of Virginia · Charlottesville, Virginia and 1 other locations · NCT06831968

• Using mobile health to prevent postpartum depression

  This study is testing a new mobile health program that combines counseling and support to see if it can help pregnant women at risk of postpartum depression feel better after giving birth.

  Recruiting at 2 sites The University of Hong Kong · Hong Kong, Pokfulam and 1 other locations · NCT06777563

• Childbirth education program to prevent postpartum depression in teenage mothers

  This study is testing a childbirth education program for first-time teenage mothers in Ethiopia to see if it can help prevent postpartum depression and improve their overall well-being.

  Recruiting The Hong Kong Polytechnic University · Bahir Dar, Amhara and 3 other locations · NCT06698107

• Exploring the effects of transcutaneous vagus nerve stimulation on postpartum mental health

  This study is testing if a new treatment using gentle electrical stimulation can help new moms avoid mood swings and depression after giving birth.

  Recruiting University Hospital Tuebingen · Tübingen, Baden-Wurttemberg · NCT06682689

Related topics

Quick answers

How many Postpartum Depression (PPD) clinical trials are recruiting right now?

23, as of November 12, 2026. 3 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (11 trials), China (2 trials), Ethiopia (1 trial), Turkey (Türkiye) (1 trial), Switzerland (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 2, Phase 4: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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