Improving support for mothers with depression to enhance HIV prevention in Malawi

Addressing Perinatal Depression and PMTCT Adherence in Malawi: A Couple-based Approach

['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10924679

This study is looking at how involving partners can help mothers with perinatal depression stick to their HIV prevention plans, making it easier for them to communicate and support each other while getting the care they need in Zomba, Malawi.

Quick facts

Phase['FUNDING_OTHER']
Study typeNih_funding
SexAll
SponsorUNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded)
Locations1 site (SAN FRANCISCO, UNITED STATES)
Trial IDNIH-10924679 on ClinicalTrials.gov

What this research studies

This research focuses on developing a couple-based intervention to help mothers experiencing perinatal depression improve their adherence to HIV prevention strategies. By involving male partners, the study aims to enhance communication and support systems, which are crucial for effective management of depression and adherence to antiretroviral therapy. The intervention will be tested in antenatal and HIV care settings in Zomba, Malawi, utilizing problem-solving therapy techniques tailored for couples. The goal is to create a supportive environment that fosters better health outcomes for both mothers and their infants.

Who could benefit from this research

Good fit: Ideal candidates for this research are pregnant women in Malawi who are experiencing perinatal depression and their male partners.

Not a fit: Patients who are not experiencing perinatal depression or are not involved in the PMTCT program may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could significantly reduce the rates of HIV transmission from mothers to infants by improving adherence to prevention strategies.

How similar studies have performed: Previous research has shown that couple-based interventions can effectively improve health outcomes in similar contexts, suggesting potential for success in this approach.

Where this research is happening

SAN FRANCISCO, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.