Condition

Methamphetamine Use Disorder clinical trials and research

• 11Clinical trials
• 18NIH research projects
• 4Countries

Newest Methamphetamine Use Disorder clinical trials

All recruiting trials (11)

• Tirzepatide for methamphetamine use disorder (phase 2)

  This phase 2 trial tests whether weekly tirzepatide injections can help adults with moderate to severe methamphetamine use disorder reduce use and improve outcomes compared with placebo.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Los Angeles, California and 3 other locations · NCT07825857

• Psilocybin Therapy for MeUD and HIV

  This study tests whether a single psilocybin dose, paired with motivational support therapy, can help people with HIV and moderate-to-severe methamphetamine use disorder stop using methamphetamine.

  Recruiting Phase 2 University of California, San Francisco · San Francisco, California · NCT07756736

• ECG changes in adults using methamphetamine with and without psychosis

  This project will see if heart ECG measurements differ between adults hospitalized for methamphetamine use who have psychosis and those who do not.

  Recruiting Elazığ Mental Health and Diseases Hospital · Elâzığ, Elâzığ · NCT07459244

• Benefits of reducing methamphetamine use

  This study will try contingency management to see if cutting back on methamphetamine improves physical, mental, and social health for adults with moderate-to-severe methamphetamine use disorder.

  Recruiting University of Kentucky · Lexington, Kentucky · NCT07226596

• CHAMPION: Combining HIV Prevention and Meth Treatment for HIV-Negative MSM

  This pilot test will see if two mobile health tools can help HIV-negative men who have sex with men who use meth take PrEP more consistently.

  Recruiting University of California, San Diego · San Francisco, California · NCT07213258

• Methamphetamine cue-reactivity and cognitive reappraisal in men with methamphetamine use disorder

  This project will test whether cognitive reappraisal reduces methamphetamine cue-triggered brain and physiological responses during abstinence in men with methamphetamine use disorder and whether effects differ between men who have sex with men (MSM) and non-MSM.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT07086014

• Troriluzole and methamphetamine response

  This study will see if taking troriluzole changes how methamphetamine affects adults with methamphetamine use disorder.

  Recruiting Early Phase 1 University of Kentucky · Lexington, Kentucky · NCT06989853

• Psilocybin treatment to help stop methamphetamine use

  This pilot will try a single 25 mg dose of psilocybin in people in residential treatment for methamphetamine use to see if it helps them stay abstinent, reduce craving, improve mood, and support cognitive function.

  Recruiting Early Phase 1 Louisiana State University Health Sciences Center Shreveport · Shreveport, Louisiana · NCT06899594

• Long-term high-dose lisdexamfetamine treatment for methamphetamine use disorder

  This trial will try giving adults with moderate to severe methamphetamine use disorder a 25-week course of high-dose lisdexamfetamine plus their usual care to see if it helps them stay in treatment and cut down on methamphetamine use compared with placebo.

  Recruiting Phase 2 Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec · NCT06788587

• Using deep TMS to treat methamphetamine use disorder in veterans

  This study is testing if a new brain treatment called deep TMS can help veterans with methamphetamine use disorder reduce their cravings and avoid relapse.

  Recruiting Stanford University · Palo Alto, California · NCT06578429

• Using brain stimulation to treat methamphetamine addiction

  This study is testing if a new brain stimulation treatment can help people with methamphetamine addiction feel less cravings and improve their thinking while they are on methadone.

  Recruiting Shanghai Mental Health Center · Shanghai, Shanghai Municipality · NCT06457230

NIH-funded research (18)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Calming cue-triggered cravings in methamphetamine use

  Seeing if teaching people with methamphetamine use disorder a thinking-based skill (cognitive reappraisal) can reduce brain and craving reactions to drug cues.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11486786

• Psilocybin for treat­ment of methamphetamine use disorder

  A study is testing whether psilocybin can help people with methamphetamine use disorder feel better and stay abstinent, starting with a small, carefully monitored group.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11443899

• Reducing Methamphetamine Use to Improve Health and Well-Being

  A clinical trial tests whether giving incentives to people with methamphetamine use disorder helps them use less meth and improves heart, immune, sleep, and psychosocial health.

  NIH research University of Kentucky · Lexington, United States · NIH-11419180

• Mobilizing Recovery Resources to Improve HIV Care for People Using Methamphetamine

  A patient-friendly project to help people living with HIV who use methamphetamine strengthen personal and community supports to stay engaged in care.

  NIH research Emory University · Atlanta, United States · NIH-11409122

• Psilocybin-assisted therapy for methamphetamine use disorder in people with HIV

  A small, carefully controlled study will test whether psilocybin, given with support, can help people living with HIV who have moderate-to-severe methamphetamine use disorder.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11394951

• Tirzepatide for Methamphetamine Use Disorder in adults with diabetes

  A study will test whether an approved diabetes drug, tirzepatide, helps adults with methamphetamine use disorder who have diabetes.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11391878

• Parkin helps brain energy stay steady in meth use disorder

  Aims to see if boosting a brain protective protein called parkin can reduce cravings and risky behavior in people (via a rat model and related studies) who struggle with methamphetamine use disorder.

  NIH research Wayne State University · Detroit, United States · NIH-11367972

• Troriluzole as a treatment for methamphetamine addiction

  This project looks at whether the medication troriluzole can help people with methamphetamine use disorder reduce cravings and drug-seeking, including those who also use opioids.

  NIH research University of Kentucky · Lexington, United States · NIH-11319049

• PROMT: a patient questionnaire to measure how methamphetamine treatment affects daily life

  This project will try out a new questionnaire that asks people with methamphetamine use disorder how medications affect their symptoms and daily functioning.

  NIH research Univ of Arkansas for Med Scis · Little Rock, United States · NIH-11195542

• Understanding Brain Energy in Methamphetamine Use

  This project explores how a protein called parkin helps brain cells maintain energy, which could lead to new ways to help people struggling with methamphetamine use.

  NIH research Wayne State University · Detroit, United States · NIH-11127613

• Testing a new treatment for methamphetamine use disorder

  This study is looking at how well Troriluzole works to help people who are trying to overcome methamphetamine use, by seeing how it affects their brain and behavior, and it's for anyone dealing with methamphetamine use disorder and possibly opioid use as well.

  NIH research University of Kentucky · Lexington, United States · NIH-11073609

• Testing a new naltrexone implant for treating methamphetamine use disorder.

  This study is looking at a new long-lasting implant that delivers medication to help people with Methamphetamine Use Disorder stay off meth, either on its own or with another medication, to see how well it works and if it's safe for you.

  NIH research Biocorrx Pharmaceuticals INC · Anaheim, United States · NIH-11042242

• Understanding how methamphetamine and HIV affect the brain

  This study is looking at how HIV and methamphetamine use affect the brain, especially in areas that help with thinking and memory, to better understand how these factors might lead to problems with brain function.

  NIH research Yale University · New Haven, United States · NIH-11039952

• Understanding how a protein helps brain cells manage energy in people with methamphetamine use disorder

  This study is looking at how a protein called parkin can help brain cells stay energized and reduce cravings for methamphetamine, with the hope of finding better treatments for people dealing with meth addiction.

  NIH research Wayne State University · Detroit, United States · NIH-10930873

• Developing a long-lasting treatment for methamphetamine addiction

  This study is working on a new treatment for people with methamphetamine use disorder by developing a special antibody that can help lessen the effects of the drug, making it easier for them to stick to their recovery plan.

  NIH research Intervexion Therapeutics, LLC · Little Rock, United States · NIH-10890735

• Evaluating a survey tool for patient outcomes in treating methamphetamine use disorder.

  This study is creating a survey to help understand how people feel and what they experience while getting treatment for methamphetamine use, so we can find better ways to support their recovery beyond just stopping drug use.

  NIH research Univ of Arkansas for Med Scis · Little Rock, United States · NIH-10789055

• Using ketamine to help people with methamphetamine addiction

  This study is looking at whether ketamine can help people who are trying to overcome methamphetamine addiction by reducing cravings and improving their mental health, and it’s designed for those who are struggling with this issue.

  NIH research The Emmes Company, LLC · Rockville, United States · NIH-10720987

• Investigating genetic risks associated with Methamphetamine Use Disorder

  This study is looking at how differences in a specific gene might affect how methamphetamine impacts the brain, especially when it comes to brain inflammation and thinking skills during recovery, with the goal of finding better ways to help people dealing with meth addiction.

  NIH research University of Hawaii at Manoa · Honolulu, United States · NIH-10668210

Related topics

Quick answers

How many Methamphetamine Use Disorder clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in United States (8 trials), Canada (1 trial), Turkey (Türkiye) (1 trial), China (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Early Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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