Investigating genetic risks associated with Methamphetamine Use Disorder
Official title: L-type Calcium Channel SNP rs1006737: characterizing the genetic risks in MUD (Methamphetamine Use Disorder)
Funded at University of Hawaii at Manoa · NIH-10668210 · Data updated 2026-11-12
This study is looking at how differences in a specific gene might affect how methamphetamine impacts the brain, especially when it comes to brain inflammation and thinking skills during recovery, with the goal of finding better ways to help people dealing with meth addiction.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Hawaii at Manoa NIH-funded |
| Lab location | 1 site (Honolulu, United States) |
| Project start | September 30, 2023 |
| Project end | September 29, 2025 |
| Funding year | 2023 |
| Award (this year) | $218,250 |
| NIH project number | 1R03DA055970-01A1 |
| Project ID | NIH-10668210 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of methamphetamine use who may be experiencing cognitive dysfunction or other related mental health issues.
✕Less likely to help
Patients who have not used methamphetamine or do not have any cognitive dysfunction related to substance use may not benefit from this research.
What this research studies
This research focuses on understanding how genetic variations in the L-type calcium channel gene may influence the effects of methamphetamine on the brain. It examines the relationship between methamphetamine use, brain inflammation, and cognitive dysfunction, particularly during periods of abstinence. By studying these genetic factors, the research aims to uncover mechanisms that could lead to improved treatment strategies for individuals struggling with methamphetamine addiction.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for individuals with Methamphetamine Use Disorder by targeting genetic factors that influence recovery.
How similar studies have gone: While the specific genetic focus on L-type calcium channels in the context of methamphetamine use is novel, similar research has shown that understanding genetic influences can lead to advancements in treatment for other substance use disorders.
Where this research is happening
-
University of Hawaii at Manoa
Honolulu, United States Active
Researchers
- Principal investigator: Andres, Marilou a. — University of Hawaii at Manoa
- Study coordinator: Andres, Marilou a.
Related research
Other NIH-funded projects on the same topics.
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-
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-
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Psilocybin-assisted therapy for methamphetamine use disorder in people with HIV
A small, carefully controlled study will test whether psilocybin, given with support, can help people living with HIV who have moderate-to-severe methamphetamine use disorder.
-
Tirzepatide for Methamphetamine Use Disorder in adults with diabetes
A study will test whether an approved diabetes drug, tirzepatide, helps adults with methamphetamine use disorder who have diabetes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.