Tirzepatide for Methamphetamine Use Disorder in adults with diabetes
Official title: Randomized Controlled Trial of Tirzepatide for Methamphetamine Use Disorder
Funded at Ut Southwestern Medical Center · NIH-11391878 · Data updated 2026-11-12
A study will test whether an approved diabetes drug, tirzepatide, helps adults with methamphetamine use disorder who have diabetes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | August 1, 2026 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $2,792,991 |
| NIH project number | 1UG3DA066252-01 |
| Project ID | NIH-11391878 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with methamphetamine use disorder who also have diabetes and meet the study’s specific criteria.
✕Less likely to help
Participants who do not have methamphetamine use disorder or diabetes, or who do not meet the study criteria, may not benefit.
What this research studies
If you have methamphetamine use disorder and diabetes, you might be eligible to participate in a tightly supervised trial testing tirzepatide, a medication that could help reduce cravings and support weight management. The study uses a randomized design to compare tirzepatide to standard care, with close monitoring of health, mood, and substance use. Researchers will track you over time to see if the treatment lowers methamphetamine use and improves related health outcomes. Participation would involve regular visits, injections, and safety checks as part of a structured protocol. Results could inform new medical options for a challenging condition that affects many adults.
Why it matters
Potential benefit: If successful, this trial could lead to a new medication option to help control methamphetamine use in adults, potentially improving health and quality of life.
How similar studies have gone: GLP-1 receptor agonists have shown promise in related substance use disorders, though this exact combination for MtUD is novel.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Jha, Manish Kumar — Ut Southwestern Medical Center
- Study coordinator: Jha, Manish Kumar
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.