Using brain stimulation to treat methamphetamine addiction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates a novel approach using paired-pulse repetitive transcranial magnetic stimulation (rTMS) targeting the frontopolar cortex and cerebellum to treat individuals with methamphetamine use disorder. The intervention aims to enhance functional connectivity in the brain, potentially reducing cravings and improving cognitive flexibility in patients undergoing methadone maintenance treatment. Participants will receive rTMS sessions designed to optimize their treatment and management of addiction, with a focus on understanding the underlying mechanisms of this intervention. The study will also assess the efficacy of this approach in reducing relapse rates among users.

Why it matters

Who can join: the full rules

Inclusion Criteria

Participants will be eligible for inclusion if they meet the following criteria:

1. Methamphetamine is the primary substance of use, and the participant meets the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria for moderate or severe methamphetamine use disorder;
2. aged 18 to 60 years;
3. normal or corrected-to-normal vision and hearing, and right-handedness;
4. primary school education or above, with the ability to understand the questionnaires and behavioral task instructions.

Exclusion Criteria

Participants will be excluded if they meet any of the following criteria:

1. presence of metal objects in the body, such as metal dentures, orthodontic braces, bone fixation plates, aneurysm clips, or other metallic implants;
2. severe physical illness or chronic disease, including heart disease, severe hypertension, stroke, epilepsy, or history of head trauma;
3. comorbid psychiatric disorders, such as bipolar disorder, schizophrenia, or severe depression;
4. previous participation in transcranial magnetic stimulation- or electroencephalography-related studies;
5. refusal to participate in the study, poor compliance, or any other contraindications to transcranial magnetic stimulation.

Where it's running

• Min Zhao, PhD
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Study coordinator: Min Zhao, PhD
• Email: drminzhao@gmail.com
• Phone: 64387250

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Tirzepatide for methamphetamine use disorder (phase 2)

  This phase 2 trial tests whether weekly tirzepatide injections can help adults with moderate to severe methamphetamine use disorder reduce use and improve outcomes compared with placebo.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Los Angeles, California and 3 other locations · NCT07825857

• Psilocybin Therapy for MeUD and HIV

  This study tests whether a single psilocybin dose, paired with motivational support therapy, can help people with HIV and moderate-to-severe methamphetamine use disorder stop using methamphetamine.

  Recruiting Phase 2 University of California, San Francisco · San Francisco, California · NCT07756736

• ECG changes in adults using methamphetamine with and without psychosis

  This project will see if heart ECG measurements differ between adults hospitalized for methamphetamine use who have psychosis and those who do not.

  Recruiting Elazığ Mental Health and Diseases Hospital · Elâzığ, Elâzığ · NCT07459244

• Benefits of reducing methamphetamine use

  This study will try contingency management to see if cutting back on methamphetamine improves physical, mental, and social health for adults with moderate-to-severe methamphetamine use disorder.

  Recruiting University of Kentucky · Lexington, Kentucky · NCT07226596

• CHAMPION: Combining HIV Prevention and Meth Treatment for HIV-Negative MSM

  This pilot test will see if two mobile health tools can help HIV-negative men who have sex with men who use meth take PrEP more consistently.

  Recruiting University of California, San Diego · San Francisco, California · NCT07213258

• Methamphetamine cue-reactivity and cognitive reappraisal in men with methamphetamine use disorder

  This project will test whether cognitive reappraisal reduces methamphetamine cue-triggered brain and physiological responses during abstinence in men with methamphetamine use disorder and whether effects differ between men who have sex with men (MSM) and non-MSM.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT07086014

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.