Understanding Brain Energy in Methamphetamine Use
Investigating Parkin-mediated Neuronal Energy Maintenance in Methamphetamine Use Disorder
This project explores how a protein called parkin helps brain cells maintain energy, which could lead to new ways to help people struggling with methamphetamine use.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-11127613 on NIH RePORTER |
What this research studies
Many people who use methamphetamine heavily face serious health problems, and there isn't an approved medication to help them quit. This research looks at a protein called parkin, which is important for keeping brain cells energized. We believe that by supporting brain energy, parkin might reduce cravings and harmful behaviors linked to methamphetamine use. The goal is to discover new ways to protect brain cells from the damage caused by methamphetamine and develop new treatments.
Who could benefit from this research
Good fit: This foundational research is for anyone interested in future treatments for methamphetamine use disorder, especially those who experience severe cravings and neurological issues.
Not a fit: Patients not affected by methamphetamine use disorder would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could identify new drug targets to develop the first FDA-approved medication for methamphetamine use disorder, offering hope to those who struggle to quit.
How similar studies have performed: This project tests a novel hypothesis about how parkin affects brain energy in methamphetamine use, building on preliminary data from rat models.
Where this research is happening
Detroit, United States
- Wayne State University — Detroit, United States (Active)
Researchers
- Principal investigator: Moszczynska, Anna — Wayne State University
- Study coordinator: Moszczynska, Anna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.