Testing a new treatment for methamphetamine use disorder
Official title: Advancing Troriluzole as a Treatment for Methamphetamine Use Disorder: A Human Laboratory Study
Funded at University of Kentucky · NIH-11073609 · Data updated 2026-11-12
This study is looking at how well Troriluzole works to help people who are trying to overcome methamphetamine use, by seeing how it affects their brain and behavior, and it's for anyone dealing with methamphetamine use disorder and possibly opioid use as well.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | April 15, 2025 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $634,048 |
| NIH project number | 1R01DA060632-01A1 |
| Project ID | NIH-11073609 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with methamphetamine use disorder, particularly those who may also have opioid use disorder.
✕Less likely to help
Patients who do not have a history of methamphetamine use or those with other substance use disorders unrelated to methamphetamine may not benefit from this research.
What this research studies
This research investigates the effectiveness of Troriluzole, a medication aimed at treating methamphetamine use disorder (MUD). The study will assess how this drug impacts brain chemistry and behavior related to methamphetamine use, particularly focusing on its effects on glutamate systems that are disrupted by the drug. Participants will be involved in a controlled environment where their responses to Troriluzole will be monitored, providing valuable data on its potential as a treatment option. The goal is to find a more effective way to help individuals struggling with MUD and co-occurring opioid use disorder.
Why it matters
Potential benefit: If successful, this research could lead to a new treatment option that significantly reduces methamphetamine use and improves recovery outcomes for patients.
How similar studies have gone: Previous research has shown promise in targeting glutamate systems for treating substance use disorders, suggesting that this approach could be effective.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Stoops, William Walton — University of Kentucky
- Study coordinator: Stoops, William Walton
Related research
Other NIH-funded projects on the same topics.
-
Calming cue-triggered cravings in methamphetamine use
Seeing if teaching people with methamphetamine use disorder a thinking-based skill (cognitive reappraisal) can reduce brain and craving reactions to drug cues.
-
Psilocybin for treatment of methamphetamine use disorder
A study is testing whether psilocybin can help people with methamphetamine use disorder feel better and stay abstinent, starting with a small, carefully monitored group.
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Reducing Methamphetamine Use to Improve Health and Well-Being
A clinical trial tests whether giving incentives to people with methamphetamine use disorder helps them use less meth and improves heart, immune, sleep, and psychosocial health.
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Mobilizing Recovery Resources to Improve HIV Care for People Using Methamphetamine
A patient-friendly project to help people living with HIV who use methamphetamine strengthen personal and community supports to stay engaged in care.
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Psilocybin-assisted therapy for methamphetamine use disorder in people with HIV
A small, carefully controlled study will test whether psilocybin, given with support, can help people living with HIV who have moderate-to-severe methamphetamine use disorder.
-
Tirzepatide for Methamphetamine Use Disorder in adults with diabetes
A study will test whether an approved diabetes drug, tirzepatide, helps adults with methamphetamine use disorder who have diabetes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.