Understanding how a protein helps brain cells manage energy in people with methamphetamine use disorder
Investigating Parkin-mediated Neuronal Energy Maintenance in Methamphetamine Use Disorder
['FUNDING_R01'] · WAYNE STATE UNIVERSITY · NIH-10930873
This study is looking at how a protein called parkin can help brain cells stay energized and reduce cravings for methamphetamine, with the hope of finding better treatments for people dealing with meth addiction.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WAYNE STATE UNIVERSITY (nih funded) |
| Locations | 1 site (DETROIT, UNITED STATES) |
| Trial ID | NIH-10930873 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a protein called parkin in helping brain cells maintain energy levels in individuals struggling with methamphetamine use disorder. Using a rat model, the study explores how increasing parkin levels in a specific brain area can reduce cravings and addictive behaviors associated with methamphetamine. The researchers aim to understand the connection between parkin, mitochondrial health, and the brain's energy production, which is often disrupted by methamphetamine use. By identifying new drug targets, this research could lead to better treatment options for those affected by this disorder.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of heavy methamphetamine use who are struggling with cravings and addiction.
Not a fit: Patients who have not used methamphetamine or those with mild or no addiction issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for methamphetamine use disorder, potentially reducing cravings and improving recovery outcomes.
How similar studies have performed: While the specific approach of targeting parkin in methamphetamine use disorder is novel, similar research has shown promise in understanding the role of mitochondrial health in addiction.
Where this research is happening
DETROIT, UNITED STATES
- WAYNE STATE UNIVERSITY — DETROIT, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MOSZCZYNSKA, ANNA — WAYNE STATE UNIVERSITY
- Study coordinator: MOSZCZYNSKA, ANNA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome