Calming cue-triggered cravings in methamphetamine use
Official title: Cue Reactivity Modulation in Methamphetamine Use Disorder
Funded at Icahn School of Medicine at Mount Sinai · NIH-11486786 · Data updated 2026-11-12
Seeing if teaching people with methamphetamine use disorder a thinking-based skill (cognitive reappraisal) can reduce brain and craving reactions to drug cues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 30, 2023 |
| Project end | February 28, 2029 |
| Funding year | 2026 |
| Award (this year) | $834,725 |
| NIH project number | 4R33DA056779-03 |
| Project ID | NIH-11486786 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with current or recent methamphetamine use disorder who can attend in-person EEG sessions and participate in brief cognitive reappraisal training are ideal candidates.
✕Less likely to help
People without methamphetamine use disorder, those unable to undergo EEG, or those unwilling to complete in-person visits and training are unlikely to benefit from this work.
What this research studies
You would come to Mount Sinai for sessions where we show images or reminders linked to methamphetamine while measuring brain responses with EEG to find a signal called the late positive potential (LPP). In the first phase we compare LPP levels across people with different histories of meth use and abstinence to find objective markers of cue‑reactivity. In the second phase we follow people over time, teach a brief cognitive reappraisal technique to help change how they think about drug cues, and repeat EEG and clinical measures to see if cue responses and cravings decrease. Visits are in person and include EEG testing, training in the coping skill, and follow-up visits to track changes.
Why it matters
Potential benefit: If successful, this could lower cue-triggered craving and relapse risk by giving a simple coping skill and a brain-based way to track progress.
How similar studies have gone: Related brain-marker and cognitive reappraisal approaches have shown promise in other substance use disorders, but using LPP plus cognitive reappraisal specifically for methamphetamine is relatively new.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Parvaz, Muhammad Adeel — Icahn School of Medicine at Mount Sinai
- Study coordinator: Parvaz, Muhammad Adeel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.