Reset-INSPIRE: See if CGM can reveal insulin sensitivity in people at risk for MASLD

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates how CGM-derived metrics correspond with traditional OGTT measures of insulin sensitivity in adults aged 21 to 70 who do not have diabetes. It compares real-time CGM data with established OGTT-based assessments under both controlled and real-world conditions to understand individual glucose responses and insulin resistance. The goal is to develop and validate a CGM-based approach for assessing insulin sensitivity related to MASLD and cardiometabolic risk. Recruitment is limited to English-speaking adults without diabetes, with site-specific assessments conducted at the Singapore site. Findings may illuminate early metabolic dysfunction and inform targeted management strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adults aged between 21 and 70 years (including 70 yrs old) at the time of screening
2. Able to speak and understand English
3. No past history of acute myocardial infarction (heart attack), stroke or heart failure
4. Able to understand and voluntarily provide written informed consent prior to any study specific procedures.
5. No current diagnosis of type 1 or type 2 diabetes, and not taking glucose-lowering medications.
6. Willing and able to comply with all scheduled study procedures.

Exclusion Criteria:

1. Known diagnosis of diabetes mellitus (type 1 or type 2), or use of antidiabetic medication.
2. Current or recent (within 3 months) use of medications known to affect glucose, including but not limited to corticosteroids.
3. Known history of liver disease or abnormal liver function deemed clinically significant by the investigator who is a medical doctor.
4. Renal impairment, defined as eGFR ≤ 60mL/min/1.73m\^2
5. Known pregnancy, plans to become pregnant during the study period, or currently breastfeeding, or
6. Known allergy or intolerance to CGM adhesives or inability to comply with CGM sensor placement, or
7. Any medical, psychiatric, or social condition that, in the opinion of the investigator, would interfere with the participant's ability to adhere to study procedures or would pose additional risk.
8. Participation in another interventional clinical trial within the past 3 months.

Where it's running

• MD6, Centre for Translational Medicine, 14 Medical Drive, Singapore 117599
  Singapore, Singapore, Singapore Recruiting

Study contacts

• Principal investigator: Roger Sik Yin Foo, MD — National University of Singapore (NUS), National University Hospital (NUH)
• Study coordinator: Benjamin Jia-Hui Loh, PhD
• Email: benjaminloh82@nus.edu.sg
• Phone: +65-89430875

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.