Understanding Them1's Role in Fatty Liver Disease
Them1-Mediated Metabolic Regulation and Pathogenic Role in MASLD
This research explores how a protein called Them1 contributes to fatty liver disease when people eat too much.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11189816 on NIH RePORTER |
What this research studies
Many people develop fatty liver disease, or MASLD, often linked to eating more calories than needed. This project looks at a specific protein called Them1, which usually helps our bodies store energy. We believe that in people with obesity, Them1 might start working against the body, causing fat to build up in the liver and making it harder for the body to use sugar properly. By understanding how Them1 works, we hope to find new ways to help manage MASLD and improve liver health.
Who could benefit from this research
Good fit: This foundational research does not involve direct patient participation but aims to benefit individuals living with or at risk for metabolic dysfunction-associated steatotic liver disease (MASLD).
Not a fit: Patients whose liver disease is not related to metabolic dysfunction or overnutrition may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could identify new targets for medications or lifestyle changes to prevent or treat MASLD.
How similar studies have performed: This research builds on preliminary findings to explore novel mechanisms of Them1 in MASLD, aiming to uncover new therapeutic targets.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Cohen, David E. — Brigham and Women's Hospital
- Study coordinator: Cohen, David E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.