Condition

Metastatic Hepatocellular Carcinoma clinical trials and research

• 13Clinical trials
• 11Countries

Newest Metastatic Hepatocellular Carcinoma clinical trials

All recruiting trials (13)

• Morning versus afternoon immunotherapy for advanced or metastatic solid tumors

  This trial tests whether giving standard immune checkpoint inhibitor therapy in the morning versus the afternoon changes outcomes for adults with advanced or metastatic solid tumors.

  Recruiting Phase 4 OHSU Knight Cancer Institute · Portland, Oregon · NCT07405086

• PF-08634404 alone or with ipilimumab for adults with advanced hepatocellular carcinoma not removable by surgery

  This tests PF-08634404 by itself and together with ipilimumab in adults whose hepatocellular carcinoma is advanced and cannot be removed surgically.

  Recruiting at 60 sites Phase 1/2 Pfizer · Irvine, California and 59 other locations · NCT07227012

• Celecoxib with durvalumab and tremelimumab for advanced liver cancer

  This phase II trial tests whether adding the oral drug celecoxib to the immunotherapy drugs durvalumab and tremelimumab helps people with advanced or metastatic liver cancer.

  Recruiting at 3 sites Phase 2 Emory University · Atlanta, Georgia and 3 other locations · NCT07174570

• Evaluating TYRA-430 for advanced liver and solid tumors with specific genetic changes

  This study is testing a new drug called TYRA-430 to see if it can help people with advanced liver and other solid tumors that have certain genetic changes.

  Recruiting at 15 sites Phase 1 Tyra Biosciences, Inc · Los Angeles, California and 15 other locations · NCT06915753

• Sapanisertib plus cabozantinib for metastatic liver cancer with beta-catenin changes

  This trial tests whether adding sapanisertib to cabozantinib helps people with metastatic liver cancer that has a beta-catenin gene change.

  Recruiting at 4 sites Phase 1/2 National Cancer Institute (NCI) · Irvine, California and 3 other locations · NCT06811116

• Evaluating ALN-BCAT for liver cancer treatment

  This study is testing a new treatment called ALN-BCAT, alone and with another drug, to see if it can safely help people with advanced liver cancer.

  Recruiting at 22 sites Phase 1 Alnylam Pharmaceuticals · Phoenix, Arizona and 22 other locations · NCT06600321

• Testing BGB-B2033 alone or with Tislelizumab for advanced solid tumors

  This study is testing a new treatment called BGB-B2033, alone or with another drug, to see if it can help people with advanced solid tumors feel better.

  Recruiting at 50 sites Phase 1/2 BeOne Medicines · Birmingham, Alabama and 50 other locations · NCT06427941

• Testing lower doses of atezolizumab for cancer treatment

  This study is testing whether lower doses of atezolizumab can effectively treat adults with advanced cancer while causing fewer side effects.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06066138

• Personalized vaccine combined with pembrolizumab for advanced solid tumors

  This study is testing a new personalized cancer vaccine combined with pembrolizumab to see if it helps people with advanced solid tumors fight their cancer better.

  Recruiting Phase 1/2 Mayo Clinic · Jacksonville, Florida · NCT05269381

• Combining atezolizumab with a multi-kinase inhibitor for advanced liver cancer treatment

  This study is testing if adding atezolizumab to either cabozantinib or lenvatinib can help people with advanced liver cancer live longer and feel better compared to just taking the multi-kinase inhibitor alone.

  Recruiting at 10 sites Phase 2 Academic and Community Cancer Research United · Scottsdale, Arizona and 15 other locations · NCT05168163

• Combining Tumor Treating Fields with Cabozantinib or Pembrolizumab and Nab-Paclitaxel for Advanced Solid Tumors

  This study is testing a new treatment that combines tumor treating fields with two different cancer drugs to see if it helps people with advanced solid tumors in the abdomen or chest.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT05092373

• GPC3 targeted CAR-T cell therapy for advanced liver cancer

  This study is testing a new immune therapy using modified T cells to see if it can help people with advanced liver cancer that has a specific marker called GPC3.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05003895

• Using radiation therapy to treat metastatic gastrointestinal cancers

  This study tests if adding radiation therapy to immunotherapy can help people with metastatic gastrointestinal cancers feel better and improve their disease status.

  Recruiting University of California, San Francisco · San Francisco, California and 1 other locations · NCT04221893

Related topics

Quick answers

How many Metastatic Hepatocellular Carcinoma clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (13 trials), South Korea (3 trials), Taiwan (2 trials), Italy (2 trials), China (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 5, Phase 1/2: 4, Phase 2: 2, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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