Identifying biomarkers for aggressive prostate cancer
Official title: Biomarker Discovery & Validation for Early Localized Prostate Cancer Administrative Core
Funded at Old Dominion University · NIH-10911311 · Data updated 2026-11-12
This study is looking for special markers in prostate fluids and tumor tissues to help tell the difference between aggressive and non-aggressive prostate cancer, so that patients can get more personalized treatment based on their specific risk.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Old Dominion University NIH-funded |
| Lab location | 1 site (Norfolk, United States) |
| Project start | September 2, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $330,184 |
| NIH project number | 5U2CCA271894-04 |
| Project ID | NIH-10911311 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men who have recently been diagnosed with localized prostate cancer.
✕Less likely to help
Patients with advanced prostate cancer or those who do not have localized disease may not benefit from this research.
What this research studies
This research focuses on finding specific biological markers that can help distinguish between aggressive and non-aggressive forms of localized prostate cancer. By analyzing prostate fluids and tumor tissues, the study aims to develop and validate new tests that can accurately identify patients at risk for more severe disease. The approach combines proteogenomic techniques to enhance early detection and improve risk stratification for patients. Ultimately, this research seeks to provide better guidance for treatment decisions based on individual risk profiles.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and tailored treatment plans for men with localized prostate cancer.
How similar studies have gone: Previous research has shown promise in using biomarkers for cancer detection, indicating that this approach could yield significant advancements.
Where this research is happening
-
Old Dominion University
Norfolk, United States Active
Researchers
- Principal investigator: Semmes, Oliver John — Old Dominion University
- Study coordinator: Semmes, Oliver John
Related research
Other NIH-funded projects on the same topics.
-
Deep learning MRI biomarkers to predict prostate cancer outcomes
A Yale-led project uses advanced MRI images and artificial intelligence to better predict how localized prostate cancer will behave in patients.
-
Exercise therapy to slow progression in localized prostate cancer on active surveillance
A study will test whether a structured home-based exercise program helps men with localized prostate cancer who are on active surveillance avoid moving to treatment or worsening, compared with usual care.
-
Biomarkers to identify aggressive prostate cancer early
A patient-friendly program to find and validate biomarkers in urine and tumor tissue that can flag aggressive prostate cancer early so men can get the right treatment sooner.
-
Home walking program for men on active surveillance for low-risk prostate cancer
This project sees if a year-long home treadmill walking program can change cancer-related markers and help men with low-grade prostate cancer on active surveillance avoid early treatment.
-
Precision pre-surgery therapy for high-risk PTEN-loss prostate cancer
This grant plans a targeted, pre-surgical treatment for men with high-risk localized prostate cancer who have PTEN loss, using intensified hormone therapy plus an AKT inhibitor before surgery.
-
Better tests to find aggressive early prostate cancer
This project develops urine and tissue biomarker tests and decision tools to help men with early prostate cancer learn whether their cancer is likely to be aggressive and needs treatment.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.