Home walking program for men on active surveillance for low-risk prostate cancer
Randomized Trial of Exercise Therapy on Markers of Progression in Localized Prostate Cancer
['FUNDING_R01'] · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · NIH-11387134
This project sees if a year-long home treadmill walking program can change cancer-related markers and help men with low-grade prostate cancer on active surveillance avoid early treatment.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BECKMAN RESEARCH INSTITUTE/CITY OF HOPE (nih funded) |
| Locations | 1 site (DUARTE, UNITED STATES) |
| Trial ID | NIH-11387134 on ClinicalTrials.gov |
What this research studies
You would be one of 122 men recently diagnosed with low-grade, localized prostate cancer and starting active surveillance. Half of participants are randomly assigned to a 12-month home-based walking program (treadmill walking five days a week at moderate intensity) supported by a telemedicine platform called TeleMed-X, while the other half receive usual care plus general activity advice. Doctors will monitor PSA, repeat prostate biopsies, multi-parametric MRI, and blood/tissue markers to see whether exercise changes tumor molecular features linked to progression. The main goal is to reduce biological signs called 'nimbosus' that are associated with needing definitive treatment.
Who could benefit from this research
Good fit: Ideal candidates are men with newly diagnosed, low-grade localized prostate cancer who have chosen active surveillance, are relatively inactive, and can safely walk on a treadmill.
Not a fit: Men with higher-risk prostate cancer, those already exercising at similar intensity, or those medically unable to perform treadmill walking are unlikely to benefit from this intervention.
Why it matters
Potential benefit: If successful, this low-cost, low-toxicity approach could reduce the chance of needing surgery or radiation by slowing biological signs of progression.
How similar studies have performed: Exercise has been linked to better overall health and some improved cancer outcomes, but using a home walking program to change prostate tumor molecular markers and reduce progression is relatively novel and not yet proven.
Where this research is happening
DUARTE, UNITED STATES
- BECKMAN RESEARCH INSTITUTE/CITY OF HOPE — DUARTE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JONES, LEE W — BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
- Study coordinator: JONES, LEE W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.