Evaluating gene expression tests for localized prostate cancer treatment decisions
Official title: Determining the clinical impact of gene expression testing in localized prostate cancer
Funded at University of Michigan at Ann Arbor · NIH-10913497 · Data updated 2026-11-12
This study is looking at how gene testing can help find the best treatment for men with localized prostate cancer, so they can avoid unnecessary treatments and get the right care based on their individual risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 1, 2019 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $164,834 |
| NIH project number | 5R01CA240991-06 |
| Project ID | NIH-10913497 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men who have been newly diagnosed with localized prostate cancer.
✕Less likely to help
Patients with advanced prostate cancer or those who have already undergone treatment may not benefit from this research.
What this research studies
This research investigates how gene expression testing can help determine the best treatment options for men with localized prostate cancer. By analyzing tissue samples and combining genetic, clinical, and pathological data, the study aims to create a universal risk score that can guide treatment decisions. The goal is to reduce unnecessary treatments while ensuring that men with higher-risk cancer receive appropriate care. Patients will be followed in a statewide registry to validate the effectiveness of this approach.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment plans for men with localized prostate cancer, improving their quality of life.
How similar studies have gone: Previous research has shown promise in using gene expression tests for cancer treatment decisions, indicating that this approach could be beneficial.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Morgan, Todd M. — University of Michigan at Ann Arbor
- Study coordinator: Morgan, Todd M.
Related research
Other NIH-funded projects on the same topics.
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Deep learning MRI biomarkers to predict prostate cancer outcomes
A Yale-led project uses advanced MRI images and artificial intelligence to better predict how localized prostate cancer will behave in patients.
-
Exercise therapy to slow progression in localized prostate cancer on active surveillance
A study will test whether a structured home-based exercise program helps men with localized prostate cancer who are on active surveillance avoid moving to treatment or worsening, compared with usual care.
-
Biomarkers to identify aggressive prostate cancer early
A patient-friendly program to find and validate biomarkers in urine and tumor tissue that can flag aggressive prostate cancer early so men can get the right treatment sooner.
-
Home walking program for men on active surveillance for low-risk prostate cancer
This project sees if a year-long home treadmill walking program can change cancer-related markers and help men with low-grade prostate cancer on active surveillance avoid early treatment.
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Precision pre-surgery therapy for high-risk PTEN-loss prostate cancer
This grant plans a targeted, pre-surgical treatment for men with high-risk localized prostate cancer who have PTEN loss, using intensified hormone therapy plus an AKT inhibitor before surgery.
-
Better tests to find aggressive early prostate cancer
This project develops urine and tissue biomarker tests and decision tools to help men with early prostate cancer learn whether their cancer is likely to be aggressive and needs treatment.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.