Examining the effects of exercise therapy on prostate cancer progression
Official title: Randomized Trial of Exercise Therapy on Markers of Progression in Localized Prostate Cancer:
Funded at Sloan-Kettering Inst Can Research · NIH-10911176 · Data updated 2026-11-12
This study is looking at how regular treadmill walking at home might help men with low-grade localized prostate cancer who are being closely monitored, to see if it can change their cancer in a positive way and possibly lessen the need for tougher treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 15, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $658,881 |
| NIH project number | 5R01CA272678-03 |
| Project ID | NIH-10911176 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men diagnosed with low-grade localized prostate cancer who are currently on active surveillance.
✕Less likely to help
Patients with advanced prostate cancer or those who are not eligible for active surveillance may not benefit from this research.
What this research studies
This research investigates how exercise therapy can impact men with low-grade localized prostate cancer who are under active surveillance. Participants will be randomly assigned to either an exercise therapy group, which involves home-based treadmill walking five days a week, or a usual care group that receives general physical activity advice. The study aims to determine if exercise can alter the molecular landscape of prostate cancer and potentially reduce the need for more aggressive treatments. The exercise sessions will be monitored through a telemedicine platform, ensuring participants receive guidance and support throughout the program.
Why it matters
Potential benefit: If successful, this research could provide a non-invasive method to manage prostate cancer progression and improve patients' quality of life.
How similar studies have gone: Previous research has shown promising results in using exercise as a therapeutic intervention for cancer patients, indicating potential for success in this approach.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Jones, Lee W — Sloan-Kettering Inst Can Research
- Study coordinator: Jones, Lee W
Related research
Other NIH-funded projects on the same topics.
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Exercise therapy to slow progression in localized prostate cancer on active surveillance
A study will test whether a structured home-based exercise program helps men with localized prostate cancer who are on active surveillance avoid moving to treatment or worsening, compared with usual care.
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Home walking program for men on active surveillance for low-risk prostate cancer
This project sees if a year-long home treadmill walking program can change cancer-related markers and help men with low-grade prostate cancer on active surveillance avoid early treatment.
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Deep learning MRI biomarkers to predict prostate cancer outcomes
A Yale-led project uses advanced MRI images and artificial intelligence to better predict how localized prostate cancer will behave in patients.
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Biomarkers to identify aggressive prostate cancer early
A patient-friendly program to find and validate biomarkers in urine and tumor tissue that can flag aggressive prostate cancer early so men can get the right treatment sooner.
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Precision pre-surgery therapy for high-risk PTEN-loss prostate cancer
This grant plans a targeted, pre-surgical treatment for men with high-risk localized prostate cancer who have PTEN loss, using intensified hormone therapy plus an AKT inhibitor before surgery.
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Better tests to find aggressive early prostate cancer
This project develops urine and tissue biomarker tests and decision tools to help men with early prostate cancer learn whether their cancer is likely to be aggressive and needs treatment.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.