Exercise therapy to slow progression in localized prostate cancer on active surveillance
Official title: Randomized Trial of Exercise Therapy on Markers of Progression in Localized Prostate Cancer
Funded at Beckman Research Institute/city of Hope · NIH-11418494 · Data updated 2026-11-12
A study will test whether a structured home-based exercise program helps men with localized prostate cancer who are on active surveillance avoid moving to treatment or worsening, compared with usual care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | September 15, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $752,423 |
| NIH project number | 5R01CA272678-05 |
| Project ID | NIH-11418494 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are men with low-grade localized prostate cancer starting active surveillance and who can commit to a 12-month home-based walking program.
✕Less likely to help
Patients unable to participate in regular baseline activity or those with contraindications to exercise may not benefit.
What this research studies
This trial enrolls men with low-grade localized prostate cancer who are starting active surveillance. Participants are randomized to an extensive home-based exercise program or standard care for 12 months, with activity guided by a telemedicine platform. The goal is to see if regular exercise can influence the cancer’s biology and delay or reduce progression, potentially improving quality of life. The study uses supervised walking 5 days a week at a target effort level and tracks changes over time through clinical assessments and biomarkers.
Why it matters
Potential benefit: If successful, exercise could become a simple, low-cost strategy to help men stay on active surveillance longer with fewer interventions.
How similar studies have gone: Previous research suggests exercise has beneficial effects on overall health and may influence cancer-related factors, but this specific approach is being tested in prostate cancer on active surveillance.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Jones, Lee W — Beckman Research Institute/city of Hope
- Study coordinator: Jones, Lee W
Related research
Other NIH-funded projects on the same topics.
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Home walking program for men on active surveillance for low-risk prostate cancer
This project sees if a year-long home treadmill walking program can change cancer-related markers and help men with low-grade prostate cancer on active surveillance avoid early treatment.
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Examining the effects of exercise therapy on prostate cancer progression
This study is looking at how regular treadmill walking at home might help men with low-grade localized prostate cancer who are being closely monitored, to see if it can change their cancer in a positive way and possibly lessen the need for tougher treatments.
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Deep learning MRI biomarkers to predict prostate cancer outcomes
A Yale-led project uses advanced MRI images and artificial intelligence to better predict how localized prostate cancer will behave in patients.
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Biomarkers to identify aggressive prostate cancer early
A patient-friendly program to find and validate biomarkers in urine and tumor tissue that can flag aggressive prostate cancer early so men can get the right treatment sooner.
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Precision pre-surgery therapy for high-risk PTEN-loss prostate cancer
This grant plans a targeted, pre-surgical treatment for men with high-risk localized prostate cancer who have PTEN loss, using intensified hormone therapy plus an AKT inhibitor before surgery.
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Better tests to find aggressive early prostate cancer
This project develops urine and tissue biomarker tests and decision tools to help men with early prostate cancer learn whether their cancer is likely to be aggressive and needs treatment.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.