Investigating how centrosome instability contributes to prostate cancer
Official title: Centrosome instability as a mechanism to promote localized prostate cancer
Funded at University of Arizona · NIH-10664978 · Data updated 2026-11-12
This study is looking at how problems with tiny structures in our cells, called centrosomes, might contribute to prostate cancer, with the hope of finding better ways to diagnose and treat the disease for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | August 22, 2019 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $585,679 |
| NIH project number | 5R01CA242226-05 |
| Project ID | NIH-10664978 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with prostate cancer, particularly those exhibiting genomic instability.
✕Less likely to help
Patients with prostate cancer that does not exhibit genomic instability or those with other types of cancer may not benefit from this research.
What this research studies
This research explores the role of centrosome instability in the development of prostate cancer. It focuses on understanding how the loss or abnormal amplification of centrosomes in prostate epithelial cells leads to genomic instability, which is a hallmark of cancer. By studying these cellular mechanisms, the research aims to uncover the underlying causes of prostate cancer and improve diagnostic and treatment strategies. Patients may benefit from insights that could lead to more effective therapies and better management of the disease.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic methods and targeted treatments for prostate cancer.
How similar studies have gone: While the specific focus on centrosome loss in prostate cancer is novel, similar research on genomic instability in other cancers has shown promising results.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Rogers, Gregory Charles — University of Arizona
- Study coordinator: Rogers, Gregory Charles
Related research
Other NIH-funded projects on the same topics.
-
Deep learning MRI biomarkers to predict prostate cancer outcomes
A Yale-led project uses advanced MRI images and artificial intelligence to better predict how localized prostate cancer will behave in patients.
-
Exercise therapy to slow progression in localized prostate cancer on active surveillance
A study will test whether a structured home-based exercise program helps men with localized prostate cancer who are on active surveillance avoid moving to treatment or worsening, compared with usual care.
-
Biomarkers to identify aggressive prostate cancer early
A patient-friendly program to find and validate biomarkers in urine and tumor tissue that can flag aggressive prostate cancer early so men can get the right treatment sooner.
-
Home walking program for men on active surveillance for low-risk prostate cancer
This project sees if a year-long home treadmill walking program can change cancer-related markers and help men with low-grade prostate cancer on active surveillance avoid early treatment.
-
Precision pre-surgery therapy for high-risk PTEN-loss prostate cancer
This grant plans a targeted, pre-surgical treatment for men with high-risk localized prostate cancer who have PTEN loss, using intensified hormone therapy plus an AKT inhibitor before surgery.
-
Better tests to find aggressive early prostate cancer
This project develops urine and tissue biomarker tests and decision tools to help men with early prostate cancer learn whether their cancer is likely to be aggressive and needs treatment.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.