Condition

Kidney Transplant Rejection clinical trials and research

• 10Clinical trials
• 4NIH research projects
• 27Countries

Newest Kidney Transplant Rejection clinical trials

All recruiting trials (10)

• Belimumab to mobilize memory B cells to help delistings for highly sensitized kidney transplant candidates

  A short belimumab course is being tested to see if it can reveal memory B cells that target donor HLAs, helping to decide which donors to exclude and potentially speed up getting a transplant for highly sensitized patients.

  Recruiting Phase 2 Leiden University Medical Center · Leiden · NCT07539857

• Frexalimab versus tacrolimus to prevent kidney transplant rejection

  This trial will test whether frexalimab injections given for up to five years work as well and are as safe as tacrolimus capsules at preventing rejection in adults getting their first kidney transplant who have low-to-moderate immune risk.

  Recruiting at 73 sites Phase 2/3 Sanofi · San Francisco, California and 72 other locations · NCT07412470

• Platelet aggregation for diagnosing acute kidney transplant rejection

  This study will test whether changes in platelet activation measured from blood can help detect acute rejection in adult kidney transplant recipients.

  Recruiting University Hospital, Martin · Martin · NCT07275541

• Donor-Derived Cell-Free DNA Test for Monitoring Kidney Transplants

  This test will try whether a blood-based donor-derived cell-free DNA (dd-cfDNA) assay can detect rejection in adults who have received a kidney transplant.

  Recruiting at 6 sites Insight Molecular Diagnostics · Los Angeles, California and 9 other locations · NCT07060716

• CRISPR-edited donor kidney transplant to reduce rejection risk

  This trial will see if donor kidneys edited with CRISPR to turn off key HLA genes can lower rejection in adults with end-stage kidney disease receiving transplants.

  Recruiting Phase 1/2 American Organ Transplant and Cancer Research Institute LLC · Beijing, Changping · NCT07053462

• Tocilizumab plus standard therapy for chronic antibody-mediated rejection after kidney transplant

  This trial will try adding tocilizumab to standard treatment (plasmapheresis, IVIG, and rituximab) to see if it helps people with chronic active antibody-mediated rejection of a kidney transplant.

  Recruiting Shahid Beheshti University of Medical Sciences · Tehran · NCT07006532

• Treating antibody-mediated kidney transplant rejection with carfilzomib and belatacept

  We will test whether adding carfilzomib and belatacept to steroids and standard immunosuppression can safely reduce antibody-mediated injury in kidney transplant recipients with donor-specific antibodies.

  Recruiting at 9 sites Phase 1 National Institute of Allergy and Infectious Diseases (NIAID) · Birmingham, Alabama and 10 other locations · NCT06918990

• Using skin grafts to detect kidney transplant rejection

  This study tests whether skin grafts from kidney donors can help doctors spot early signs of kidney transplant rejection in patients.

  Recruiting at 3 sites Second Affiliated Hospital, Zhejiang University, School of Medicine · Xi'an, Shannxi and 2 other locations · NCT05600634

• Using PET scans to diagnose subclinical rejection in kidney transplant patients

  This study is testing if a special type of scan can safely spot early signs of kidney rejection in transplant patients without needing a painful biopsy.

  Recruiting University of Liege · Liège, Liège · NCT04702022

• Monitoring kidney transplant rejection using blood tests

  This study is testing if measuring certain DNA levels in the blood can help doctors better detect kidney transplant rejection in patients who are already having biopsies.

  Recruiting at 26 sites University of Alberta · Tampa, Florida and 30 other locations · NCT04239703

NIH-funded research (4)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Immunological mechanisms behind treatment-resistant kidney transplant rejection

  This grant explores why certain kidney transplant rejections don’t respond to standard treatments and what immune cells in the graft are driving that resistance.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11449432

• Investigating immune responses in kidney transplant rejection

  This study is looking at how certain immune cells in your body might affect the success of kidney transplants, especially if you've had previous infections, to help find better treatments that could reduce the need for long-term medication after surgery.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11248001

• Investigating T cells involved in kidney transplant rejection

  This study is looking at how certain immune cells called CD8+ T cells play a role in kidney transplant rejection, especially in patients who have had past infections, to help find better ways to prevent rejection and improve transplant success.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11232890

• Using a new type of immune cell therapy to prevent and treat kidney transplant rejection

  This study is exploring a new type of immune cell that could help prevent kidney transplant rejection by stopping harmful antibodies, and it's designed for people who have received a kidney transplant and want to improve their chances of success.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-10653007

Related topics

Quick answers

How many Kidney Transplant Rejection clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 27 countries. The most sites are in United States (4 trials), China (3 trials), Australia (2 trials), Czechia (2 trials), Germany (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 1, Phase 1: 1, Phase 2: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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