Using a new type of immune cell therapy to prevent and treat kidney transplant rejection
Official title: Investigating a Novel Cellular Therapy to Prevent and Treat Acute Antibody Mediated Kidney Transplant Rejection
Funded at Ohio State University · NIH-10653007 · Data updated 2026-11-12
This study is exploring a new type of immune cell that could help prevent kidney transplant rejection by stopping harmful antibodies, and it's designed for people who have received a kidney transplant and want to improve their chances of success.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | July 1, 2019 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $534,418 |
| NIH project number | 5R01AI139913-05 |
| Project ID | NIH-10653007 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have received a kidney transplant or are scheduled to undergo kidney transplantation.
✕Less likely to help
Patients who have not undergone kidney transplantation or those with conditions unrelated to transplant rejection may not benefit from this research.
What this research studies
This research investigates a novel type of immune cell, known as CD8+ TAb-supp cells, which can suppress the production of harmful antibodies that lead to kidney transplant rejection. The study aims to enhance the development of these cells and assess their effectiveness in preventing and treating acute antibody-mediated rejection (AMR) in kidney transplant recipients. By conducting pre-clinical studies using a mouse model that mimics human kidney transplant conditions, the researchers hope to establish a new therapeutic approach that could improve transplant outcomes. The team consists of experts in transplantation and immunology, ensuring a comprehensive approach to the problem.
Why it matters
Potential benefit: If successful, this research could lead to improved kidney transplant survival rates and better long-term outcomes for patients.
How similar studies have gone: Previous research has shown promise in using cellular therapies for transplant rejection, but this specific approach is novel and has not been extensively tested.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Bumgardner, Ginny L — Ohio State University
- Study coordinator: Bumgardner, Ginny L
Related research
Other NIH-funded projects on the same topics.
-
Immunological mechanisms behind treatment-resistant kidney transplant rejection
This grant explores why certain kidney transplant rejections don’t respond to standard treatments and what immune cells in the graft are driving that resistance.
-
Investigating immune responses in kidney transplant rejection
This study is looking at how certain immune cells in your body might affect the success of kidney transplants, especially if you've had previous infections, to help find better treatments that could reduce the need for long-term medication after surgery.
-
Investigating T cells involved in kidney transplant rejection
This study is looking at how certain immune cells called CD8+ T cells play a role in kidney transplant rejection, especially in patients who have had past infections, to help find better ways to prevent rejection and improve transplant success.
-
Understanding how BK virus links infection to kidney transplant rejection
This project looks at how BK polyomavirus reactivation affects kidney transplant patients and aims to use pre-transplant T cell information to tailor immunosuppression and monitoring.
-
Microbial clues to diagnose and predict infections in kidney transplant patients
A patient-focused project will look for microbial biomarkers in stool, blood, and urine to help doctors predict and diagnose infections in people who have had a kidney transplant.
-
Complement-Bound Exosomes and Kidney Transplant Immunity
This project studies how kidney transplant injury and rejection happen after surgery and whether blocking certain immune pathways during organ preservation could improve transplant outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.