Using PET scans to diagnose subclinical rejection in kidney transplant patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of 18F-FDG PET/CT imaging as a non-invasive method to diagnose subclinical rejection in kidney transplant patients. Traditionally, renal biopsies are the gold standard for detecting acute rejection, but they are invasive and carry risks. The study aims to validate PET/CT imaging as a safer alternative that can help identify patients who may benefit from corticosteroid withdrawal without the need for biopsy. The research will involve kidney transplant recipients who are monitored for signs of rejection using this imaging technique.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Kidney recipients aged over 18 and of all sexes

Exclusion Criteria:

* Pregnant patients
* Polyomavirus nephropathy
* Highly sensitised patients (historical or at 3 months Donor specific antibodies)
* No corticosteroids withdrawal allowed (second kidney transplantation or primary disease)

Where it's running

• Antoine Bouquegneau
  Liège, Liège, Belgium Recruiting

Study contacts

• Principal investigator: Francois Jouret — University of Liege
• Study coordinator: Antoine Bouquegneau
• Email: antoine.bouquegneau@gmail.com
• Phone: +32473353321

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Omnisol-preserved kidneys before transplant (hypothermic machine perfusion)

  This study tests whether using Omnisol during hypothermic machine perfusion before kidney transplant can improve early graft function compared with standard preservation.

  Recruiting Vivalyx GmbH · Rotterdam · NCT07792317

• How Propofol and Sevoflurane Affect miRNA in Living Kidney Donors

  This study tests whether using propofol or sevoflurane during donor nephrectomy changes levels of miRNAs in living kidney donors.

  Recruiting University of Gaziantep · Gaziantep, Sahinbey · NCT07760402

• Effects of general vs spinal-epidural anesthesia on kidney transplant biomarkers

  This study tests whether sevoflurane general anesthesia or combined spinal-epidural anesthesia changes markers of cellular stress and protective peptides in adults undergoing kidney transplantation.

  Recruiting University of Gaziantep · Gaziantep, State/Province · NCT07678073

• How kidney transplant patients feel about using artificial intelligence in medicine

  This international survey asks adults who have had a kidney transplant how they feel about AI tools that predict graft loss and what it might mean for their daily care.

  Recruiting at 2 sites Paris Translational Research Center for Organ Transplantation · Paris, Île-de-France Region and 1 other locations · NCT07600541

• Belimumab to mobilize memory B cells to help delistings for highly sensitized kidney transplant candidates

  A short belimumab course is being tested to see if it can reveal memory B cells that target donor HLAs, helping to decide which donors to exclude and potentially speed up getting a transplant for highly sensitized patients.

  Recruiting Phase 2 Leiden University Medical Center · Leiden · NCT07539857

• Personalized therapeutic stories for children after kidney transplant.

  We will test whether clinician-supervised AI can create age-appropriate, personalized therapeutic stories for children aged 5–12 who have received a kidney transplant and their families.

  Recruiting Paris Translational Research Center for Organ Transplantation · Paris, Île-de-France Region · NCT07532382

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.