Investigating T cells involved in kidney transplant rejection
Single Cell Analysis of Allowance CB8+ T Cells in Kidney Transplant Rejection
This study is looking at how certain immune cells called CD8+ T cells play a role in kidney transplant rejection, especially in patients who have had past infections, to help find better ways to prevent rejection and improve transplant success.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11232890 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific T cells, known as CD8+ T cells, contribute to the rejection of kidney transplants. By analyzing these cells from patients who have experienced transplant rejection, the study aims to uncover the mechanisms behind their activity and how prior infections may influence their behavior. The approach involves examining tissue samples from both human and animal models to identify patterns in T cell responses. This could lead to more effective therapies that minimize rejection and improve transplant outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have undergone kidney transplantation and are experiencing or at risk of transplant rejection.
Not a fit: Patients who have not received a kidney transplant or those with stable graft function without rejection episodes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing kidney transplant rejection, enhancing patient survival and quality of life.
How similar studies have performed: Previous research has shown promise in understanding T cell behavior in transplant rejection, suggesting that this approach could yield valuable insights.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Shi, Tiffany — University of Cincinnati
- Study coordinator: Shi, Tiffany
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.