Mass General IgG4-related Disease Center

Who could benefit from this research

What this research studies

If you join, doctors will follow you over time and collect blood, stool, and sometimes tissue samples to track changes before, during, and after treatment. The team will measure autoantibodies, identify antigen-specific B and T cells, and compare immune profiles using protein arrays, ELISAs, and specialized immunoprecipitation tests. They will also look at the gut microbiome for microbes that might trigger immune cross-reactions and study how patients respond to B-cell depletion therapies as they go into remission and later relapse. All of this is done to pinpoint what starts and sustains disease and to find markers that could warn of relapse or guide therapy.

Why it matters

Where this research is happening

• Massachusetts General Hospital
  Boston, United States Active

Researchers

• Principal investigator: Pillai, Shiv Subramaniam — Massachusetts General Hospital
• Study coordinator: Pillai, Shiv Subramaniam

Related research

Other NIH-funded projects on the same topics.

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• Anti-BCMA-CD19 CAR-T therapy for relapsed or refractory IgG4-related disease

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  This 52-week randomized trial will test whether adding 5 mg or 10 mg lenalidomide to prednisone helps adults with active proliferative IgG4‑related disease do better than prednisone alone.

  Recruiting Phase 2/3 Peking Union Medical College Hospital · Beijing · NCT07068165

• ACE1831 cell therapy for safety, effectiveness, and persistence in people with IgG4-related disease

  This trial will test ACE1831, an off-the-shelf gamma delta T cell therapy from healthy donors, to see if it is safe and helps adults with active IgG4-related disease.

  Recruiting at 11 sites Phase 1/2 Acepodia Biotech, Inc. · Atlanta, Georgia and 10 other locations · NCT07061938

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.