Identifying immune responses in a specific fibrotic disease
Defining the antigenic determinants of the adaptive immune response in IgG4-related disease
This study is looking into how the immune system works in people with IgG4-related disease to find out what specific proteins might be causing the unusual immune responses, which could help improve treatments for patients like you.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10912567 on NIH RePORTER |
What this research studies
This research investigates the immune mechanisms involved in IgG4-related disease (IgG4-RD), a condition characterized by fibrosis and immune response abnormalities. The project focuses on identifying specific self-proteins that trigger these immune responses, which could lead to better understanding and treatment options for patients. Dr. Perugino, the principal investigator, is enhancing his skills in molecular biology and statistical analysis to conduct this research effectively. The study employs advanced techniques such as single-cell sequencing and peptide-MHC yeast display libraries to explore the immune landscape of IgG4-RD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with IgG4-related disease who are experiencing symptoms related to this condition.
Not a fit: Patients with other autoimmune diseases or those not diagnosed with IgG4-related disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for patients suffering from IgG4-related disease.
How similar studies have performed: Previous research has shown promise in understanding immune responses in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Perugino, Cory — Massachusetts General Hospital
- Study coordinator: Perugino, Cory
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.