Condition

Hypoxic-Ischemic Encephalopathy clinical trials and research

• 13Clinical trials
• 11NIH research projects
• 6Countries

Newest Hypoxic-Ischemic Encephalopathy clinical trials

All recruiting trials (13)

• Wireless NIRS Sensor Use in the NICU for Monitoring on Neonates

  A wireless NIRS sensor is tested on infants in the NICU to see how well it stays on and how it notes brain signals when used alongside standard wired sensors.

  Recruiting McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT07732244

• Neonatal Neurological Observation With Video AI

  This study tests a real-time, non-contact video AI system to help monitor brain health in newborns with suspected brain injury during their hospital stay.

  Recruiting Artemis AI Labs · New York, New York and 1 other locations · NCT07628829

• Two-week intensive brain-focused therapy program for children with neurodevelopmental and chromosomal conditions

  This program will try a two-week, individualized multimodal neurorehabilitation approach for children about 4–12 years old with neurodevelopmental or chromosomal conditions to see if it improves attention, motor skills, communication, and daily functioning.

  Recruiting Healing Hope International · The Woodlands, Texas · NCT07493096

• Genome sequencing for newborns with perinatal hypoxic‑ischemic encephalopathy

  This program will try genome sequencing for newborns with moderate-to-severe hypoxic‑ischemic encephalopathy who are receiving therapeutic cooling, using parent samples to help interpret results.

  Recruiting at 2 sites Baylor College of Medicine · Houston, Texas and 1 other locations · NCT06762795

• Understanding how different anesthetics affect brain blood flow and oxygen levels during MRI

  This study is testing how different types of anesthesia affect blood flow and oxygen levels in the brain during MRI scans in kids and teens.

  Recruiting Children's Hospital Los Angeles · Los Angeles, California · NCT06195345

• Investigating eye function in babies with brain injury

  This study is trying to see how eye function in babies with brain injuries affects their development over time.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT05971446

• Optimizing hydrocortisone therapy for newborns undergoing hypothermia treatment after asphyxia

  This study is testing how to best use hydrocortisone treatment for newborns who have had trouble breathing at birth and are being cooled to help their recovery.

  Recruiting Phase 4 Semmelweis University · Budapest, Pest County · NCT05836610

• Evaluating a new treatment for newborns with brain injury from lack of oxygen

  This study is testing a new treatment for newborns with brain injuries caused by a lack of oxygen to see if it can help them recover better while they are receiving cooling therapy.

  Recruiting at 21 sites Phase 2/3 ReAlta Life Sciences, Inc. · Little Rock, Arkansas and 21 other locations · NCT05778188

• Testing Levetiracetam for treating neonatal seizures

  This study is testing how much of the medication Levetiracetam is safe to give to newborns with seizures to see if it works better than the standard treatment.

  Recruiting at 5 sites Phase 2 University of California, San Diego · San Diego, California and 5 other locations · NCT05610085

• Evaluating Sovateltide for treating brain injury in newborns

  This study is testing a new treatment called Sovateltide to see if it can help newborns with brain injuries caused by lack of oxygen during birth.

  Recruiting at 2 sites Phase 2 Pharmazz, Inc. · Mangalore, Karnataka and 3 other locations · NCT05514340

• Identifying brain injury biomarkers in patients with high ammonia levels

  This study is testing if certain brain injury markers in patients with high ammonia levels can help us understand how ammonia affects the brain and improve care for those with related metabolic disorders.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT04602325

• Identifying factors that predict recovery of consciousness in brain injury patients

  This study is trying to find out what factors help predict how well patients with brain injuries will recover their awareness after they start early rehabilitation.

  Recruiting BDH-Klinik Hessisch Oldendorf · Hessisch Oldendorf · NCT04445649

• Using melatonin to protect the brain in newborns with HIE during cooling treatment

  This study is testing whether melatonin can help protect the brains of newborns with Hypoxic-Ischemic Encephalopathy during cooling treatment to see if it improves their long-term development.

  Recruiting at 2 sites Early Phase 1 University of Florida · Gainesville, Florida and 1 other locations · NCT02621944

NIH-funded research (11)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Brain support cells in newborn brain injury after birth asphyxia

  This grant studies how brain-supporting cells called pericytes affect brain damage after a newborn experiences a lack of oxygen at birth, with potential to guide new treatments.

  NIH research Loma Linda University · Loma Linda, UNITED STATES · NIH-11482126

• Neonatal brain health: using a new NIRS approach to guide cooling therapy in newborns with HIE

  A new NIH-funded approach aims to use bedside brain oxygen and blood flow measurements to personalize cooling therapy for babies with hypoxic-ischemic encephalopathy.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11327649

• Brain-derived exosomes to detect and track newborn oxygen-related brain injury

  This project looks for tiny brain-derived particles in newborns who had low oxygen at birth to help predict how they'll recover and whether cooling will help.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11311942

• Personalized care for newborns with oxygen-related brain injury (HIE)

  We are creating a combined MRI and clinical tool to better predict long-term outcomes for newborns who had low oxygen to the brain (neonatal HIE).

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11286795

• Understanding the Link Between Maternal Infection and Brain Injury in Newborns

  This project aims to better understand how infections during pregnancy might affect a newborn's brain and lead to conditions like hypoxic-ischemic encephalopathy (HIE).

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11128376

• Improving Cooling Treatment for Newborn Brain Injury

  This project looks for better ways to guide cooling treatment for newborns who have experienced brain injury due to lack of oxygen.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11093545

• A wearable device to monitor brain health in newborns with oxygen deprivation

  This study is testing a new, affordable wearable device that helps doctors keep an eye on the brain health of newborns with a condition called hypoxic ischemic encephalopathy (HIE) by measuring important markers in real-time, so they can act quickly to help these babies.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11061897

• Using brain-derived exosomes to find biomarkers for neonatal brain injury

  This study is looking at tiny particles from the brain to see if they can help doctors better understand and track brain injuries in newborns who have had a lack of oxygen, so they can provide more personalized care and improve treatment options.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11056137

• Improving predictions for brain injury outcomes in newborns with hypoxic-ischemic encephalopathy

  This study is looking to improve how we understand and treat babies with a condition called neonatal hypoxic-ischemic encephalopathy (HIE) by using special brain scans and medical information to better identify the different types of HIE and predict how the babies will do in the future, ultimately helping doctors provi

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11017006

• Optimizing caffeine dosing for infants with brain injury due to lack of oxygen

  This study is looking at how caffeine can help protect the brains of babies with a serious condition called hypoxic-ischemic encephalopathy (HIE) while they receive cooling treatment, and it will test the best amount of caffeine to use for the best results.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10906753

• Investigating the link between maternal infections and brain injury in newborns

  This study is looking at how an infection during pregnancy, called chorioamnionitis, might increase the chances of newborns developing a serious brain condition known as hypoxic-ischemic encephalopathy (HIE), and it aims to find better ways to diagnose and prevent this risk for babies.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10877075

Related topics

Quick answers

How many Hypoxic-Ischemic Encephalopathy clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (9 trials), Hungary (1 trial), Canada (1 trial), India (1 trial), New Zealand (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 4: 1, Phase 2/3: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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