Investigating the link between maternal infections and brain injury in newborns
Official title: Maternal Chorioamnionitis and Hypoxic-Ischemic Encephalopathy: The MATCH Study
Funded at University of California, San Francisco · NIH-10877075 · Data updated 2026-11-12
This study is looking at how an infection during pregnancy, called chorioamnionitis, might increase the chances of newborns developing a serious brain condition known as hypoxic-ischemic encephalopathy (HIE), and it aims to find better ways to diagnose and prevent this risk for babies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $173,535 |
| NIH project number | 5K23HD109684-03 |
| Project ID | NIH-10877075 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include newborns who have been diagnosed with hypoxic-ischemic encephalopathy and whose mothers experienced chorioamnionitis during pregnancy.
✕Less likely to help
Patients who do not have hypoxic-ischemic encephalopathy or whose mothers did not experience chorioamnionitis are unlikely to benefit from this research.
What this research studies
This research focuses on understanding how maternal chorioamnionitis, an infection during pregnancy, affects the risk of hypoxic-ischemic encephalopathy (HIE) in newborns. HIE is a serious condition that can lead to severe neurological issues or death in infants. The study aims to clarify the relationship between maternal fever, inflammation, and the risk of HIE, using a new definition of chorioamnionitis to improve diagnosis and treatment. By analyzing clinical data and outcomes, the research seeks to enhance prevention strategies for affected newborns.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic criteria and treatment options for newborns at risk of brain injury due to maternal infections.
How similar studies have gone: Previous research has indicated a connection between maternal infections and adverse neonatal outcomes, suggesting that this study's approach could yield valuable insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Cornet, Marie — University of California, San Francisco
- Study coordinator: Cornet, Marie
Related research
Other NIH-funded projects on the same topics.
-
Brain support cells in newborn brain injury after birth asphyxia
This grant studies how brain-supporting cells called pericytes affect brain damage after a newborn experiences a lack of oxygen at birth, with potential to guide new treatments.
-
Neonatal brain health: using a new NIRS approach to guide cooling therapy in newborns with HIE
A new NIH-funded approach aims to use bedside brain oxygen and blood flow measurements to personalize cooling therapy for babies with hypoxic-ischemic encephalopathy.
-
Brain-derived exosomes to detect and track newborn oxygen-related brain injury
This project looks for tiny brain-derived particles in newborns who had low oxygen at birth to help predict how they'll recover and whether cooling will help.
-
Personalized care for newborns with oxygen-related brain injury (HIE)
We are creating a combined MRI and clinical tool to better predict long-term outcomes for newborns who had low oxygen to the brain (neonatal HIE).
-
Understanding the Link Between Maternal Infection and Brain Injury in Newborns
This project aims to better understand how infections during pregnancy might affect a newborn's brain and lead to conditions like hypoxic-ischemic encephalopathy (HIE).
-
Improving Cooling Treatment for Newborn Brain Injury
This project looks for better ways to guide cooling treatment for newborns who have experienced brain injury due to lack of oxygen.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.