Investigating the link between maternal infections and brain injury in newborns
Maternal Chorioamnionitis and Hypoxic-Ischemic Encephalopathy: The MATCH Study
This study is looking at how an infection during pregnancy, called chorioamnionitis, might increase the chances of newborns developing a serious brain condition known as hypoxic-ischemic encephalopathy (HIE), and it aims to find better ways to diagnose and prevent this risk for babies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10877075 on NIH RePORTER |
What this research studies
This research focuses on understanding how maternal chorioamnionitis, an infection during pregnancy, affects the risk of hypoxic-ischemic encephalopathy (HIE) in newborns. HIE is a serious condition that can lead to severe neurological issues or death in infants. The study aims to clarify the relationship between maternal fever, inflammation, and the risk of HIE, using a new definition of chorioamnionitis to improve diagnosis and treatment. By analyzing clinical data and outcomes, the research seeks to enhance prevention strategies for affected newborns.
Who could benefit from this research
Good fit: Ideal candidates for this research include newborns who have been diagnosed with hypoxic-ischemic encephalopathy and whose mothers experienced chorioamnionitis during pregnancy.
Not a fit: Patients who do not have hypoxic-ischemic encephalopathy or whose mothers did not experience chorioamnionitis are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic criteria and treatment options for newborns at risk of brain injury due to maternal infections.
How similar studies have performed: Previous research has indicated a connection between maternal infections and adverse neonatal outcomes, suggesting that this study's approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Cornet, Marie — University of California, San Francisco
- Study coordinator: Cornet, Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.