Improving predictions for brain injury outcomes in newborns with hypoxic-ischemic encephalopathy
Official title: Precision Medicine for Neonatal Hypoxic-Ischemic Encephalopathy: Combined Neuroimaging Clinical Approach to Link Phenotypes to Prognosis
Funded at Johns Hopkins University · NIH-11017006 · Data updated 2026-11-12
This study is looking to improve how we understand and treat babies with a condition called neonatal hypoxic-ischemic encephalopathy (HIE) by using special brain scans and medical information to better identify the different types of HIE and predict how the babies will do in the future, ultimately helping doctors provide the best care for these little ones.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | February 1, 2022 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $368,259 |
| NIH project number | 5R01NS126549-04 |
| Project ID | NIH-11017006 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are infants under 2 years of age diagnosed with hypoxic-ischemic encephalopathy.
✕Less likely to help
Patients who are older than 2 years or do not have a diagnosis of hypoxic-ischemic encephalopathy may not benefit from this research.
What this research studies
This research aims to enhance the understanding and treatment of neonatal hypoxic-ischemic encephalopathy (HIE) by developing a framework that combines brain MRI evaluations with clinical data to classify HIE and predict neurological outcomes. The team will create a specialized MRI tool to identify different types of brain lesions, which will help in distinguishing HIE subtypes and their associated clinical features. By improving the accuracy of prognosis predictions, this research seeks to inform targeted treatments and resource allocation for affected infants.
Why it matters
Potential benefit: If successful, this research could lead to more accurate predictions of neurological outcomes for newborns with HIE, allowing for tailored treatment plans.
How similar studies have gone: Previous research has shown promise in using MRI for predicting outcomes in severe cases of brain injury, but this approach to classify HIE subtypes is relatively novel.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Oishi, Kenichi — Johns Hopkins University
- Study coordinator: Oishi, Kenichi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.