Personalized care for newborns with oxygen-related brain injury (HIE)
Official title: Precision Medicine for Neonatal Hypoxic-Ischemic Encephalopathy: Combined Neuroimaging Clinical Approach to Link Phenotypes to Prognosis
Funded at Johns Hopkins University · NIH-11286795 · Data updated 2026-11-12
We are creating a combined MRI and clinical tool to better predict long-term outcomes for newborns who had low oxygen to the brain (neonatal HIE).
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | February 1, 2022 |
| Project end | January 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $409,169 |
| NIH project number | 5R01NS126549-05 |
| Project ID | NIH-11286795 on NIH RePORTER |
Who could benefit from this research
✓Could help
Newborns diagnosed with hypoxic-ischemic encephalopathy who have brain MRI scans and clinical data available, and their families willing to share follow-up developmental information.
✕Less likely to help
Children without HIE, those who do not have an MRI or necessary clinical records available, or older children beyond the neonatal period are unlikely to be eligible or benefit directly.
What this research studies
Your baby would have their brain MRI images analyzed by a new computer tool that detects and measures different kinds of brain injury, and those results would be combined with clinical information from the newborn period. Researchers will use advanced image-analysis methods to group babies into HIE subtypes and link those subtypes to later neurodevelopmental outcomes. They plan to follow babies over time so the patterns they find can help predict which infants are likely to have developmental problems even when MRIs look mild or normal. The work is based at Johns Hopkins and uses medical records and imaging from affected infants to build the prediction method.
Why it matters
Potential benefit: If successful, this could give families clearer information about a child's likely development and help clinicians tailor therapies and rehabilitation earlier.
How similar studies have gone: MRI has been useful at predicting severe outcomes in clear-cut cases, but using detailed MRI quantification combined with clinical data to improve prediction for mild-to-moderate cases is a newer approach building on recent image-analysis advances.
Where this research is happening
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Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Oishi, Kenichi — Johns Hopkins University
- Study coordinator: Oishi, Kenichi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.