Understanding the Link Between Maternal Infection and Brain Injury in Newborns
Maternal Chorioamnionitis and Hypoxic-Ischemic Encephalopathy: The MATCH Study
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11128376
This project aims to better understand how infections during pregnancy might affect a newborn's brain and lead to conditions like hypoxic-ischemic encephalopathy (HIE).
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11128376 on ClinicalTrials.gov |
What this research studies
Hypoxic-ischemic encephalopathy (HIE) is a serious brain condition affecting many newborns, often leading to severe disabilities or even death. We know that infections or inflammation during pregnancy, called chorioamnionitis, can increase a baby's risk for HIE and might make treatments less effective. This project seeks to define chorioamnionitis more precisely and understand its exact connection to HIE. By doing so, we hope to find better ways to prevent and treat this challenging condition in vulnerable newborns.
Who could benefit from this research
Good fit: This research focuses on newborns affected by hypoxic-ischemic encephalopathy (HIE) and their mothers who experienced chorioamnionitis during pregnancy.
Not a fit: Patients not directly involved in the study or those whose conditions are unrelated to HIE or chorioamnionitis may not see direct benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to improved methods for identifying newborns at risk for HIE and developing more effective prevention and treatment strategies.
How similar studies have performed: While the link between chorioamnionitis and HIE is recognized, this project aims to refine the definition of chorioamnionitis and its specific relationship to HIE risk, which is a novel approach.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CORNET, MARIE — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: CORNET, MARIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury, Autistic Disorder