Using brain-derived exosomes to find biomarkers for neonatal brain injury
Central Nervous System Derived Exosomes: A Novel Source of Biomarkers for Neonatal Hypoxic Ischemic Encephalopathy
This study is looking at tiny particles from the brain to see if they can help doctors better understand and track brain injuries in newborns who have had a lack of oxygen, so they can provide more personalized care and improve treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11056137 on NIH RePORTER |
What this research studies
This research investigates the use of central nervous system-derived exosomes as potential biomarkers for neonatal hypoxic-ischemic encephalopathy (HIE), a condition affecting newborns due to lack of oxygen. The study aims to develop non-invasive assays that can accurately assess the timing and extent of brain injury in infants, particularly during critical clinical phases. By analyzing these exosomes, researchers hope to improve the identification of infants who may not respond to current treatments like therapeutic hypothermia. This approach could lead to better monitoring and tailored therapies for affected neonates.
Who could benefit from this research
Good fit: Ideal candidates for this research are newborns diagnosed with hypoxic-ischemic encephalopathy.
Not a fit: Patients who do not have neonatal hypoxic-ischemic encephalopathy or are outside the neonatal age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatment strategies for infants suffering from neonatal hypoxic-ischemic encephalopathy.
How similar studies have performed: While the use of exosomes in this context is relatively novel, there is growing interest and preliminary success in using similar approaches for other neurological conditions.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Goetzl, Laura — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Goetzl, Laura
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.