Clinical trial Recruiting at 1 site Observational Ages 14 and up Women only

Study of gut and vaginal microbiota in women living with HIV

Official title: A Cohort Study Among HIV Infected Women:Exploring the Regulatory Mechanism of Gut and Vaginal Microbiota in HPV Infection and Cervical Lesion

Run by Peking Union Medical College Hospital · NCT05996016 · Data updated 2026-11-12

This study looks at how the balance of bacteria in the vagina affects the risk of HPV infection and cervical issues in women living with HIV in China.

More HIV Infections trials

Quick facts

Study typeObservational
Ages14 Years and up
SexWomen only
Enrollment400 (estimated)
SponsorPeking Union Medical College Hospital
Academic / other
Locations1 site (Beijing, Beijing Municipality)
StatusRecruiting
StartedJanuary 1, 2017
Main results expectedJanuary 1, 2029
Study endsJune 30, 2030
Registry record updatedDecember 9, 2025
Trial IDNCT05996016 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are women living with HIV, including those who are pregnant.

Probably not a fit

Patients who are virgins or maidens will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on women living with HIV infection to explore the relationship between vaginal microbiota imbalance and susceptibility to HPV infection, which can lead to cervical lesions. The study aims to gather data on HPV prevalence and its associated cervical lesion incidence among this population in China. By investigating the microbiota profiles, researchers hope to clarify the causal relationship between vaginal microbiota and cervical disease in women with HIV. The findings could provide insights into potential preventive measures for cervical lesions in this vulnerable group.

Why it matters

Potential benefit: If successful, this study could lead to improved understanding and prevention of cervical lesions in women living with HIV.

How similar studies have gone: While there is limited data on HPV prevalence in women living with HIV in China, similar studies in other regions have shown promising results regarding the relationship between microbiota and cervical health.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* HIV women (including pregnant);
* sign consent paper

Exclusion Criteria:

* virgin or maiden

Where it's running

  • Peking Union Medical College Hospital
    Beijing, Beijing Municipality, China
    Recruiting

Study contacts

  • Principal investigator: Wei Lyu, MD — No. 10Yi,Chaowai Street ,Chaoyang District ,Beijing ,China
  • Study coordinator: Wei Lyu, MD
  • Email: lvweipumch@163.com
  • Phone: 13501385800

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.