Self-swab versus clinician-collected HPV screening for vulnerable women in Reunion
Official title: Concordance and Acceptability of Self-screening Compared to Screening Carried Out by a Health Professional for HPV, a Risk Factor for Anal Cancer, by Swab in People Living With HIV. A Randomized Controlled Crossover Study
Run by Centre Hospitalier Universitaire de la Réunion · NCT07438080 · Data updated 2026-11-12
This study tests whether self-collected swabs work as well and feel as acceptable as clinician-collected swabs for HPV screening in vulnerable women aged 30–65.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 30 Years to 65 Years |
| Sex | Women only |
| Enrollment | 300 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de la Réunion Academic / other |
| Locations | 2 sites (Saint-Paul and 1 other locations) |
| Status | Recruiting |
| Started | April 9, 2025 |
| Main results expected | March 1, 2027 |
| Study ends | March 1, 2028 |
| Registry record updated | February 27, 2026 |
| Trial ID | NCT07438080 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women aged 30–65 in vulnerable situations who live in one of the two targeted municipalities, are supported by local social services, and agree to attend the on-site sexual health meetings.
✕Probably not a fit
People who have had a hysterectomy, who do not live in the targeted municipalities, or who refuse participation are unlikely to benefit from this study's procedures.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized crossover study compares self-collected swabs to swabs taken by a health professional for HPV detection among vulnerable women living in two municipalities of Réunion. Participants are recruited through social services and attend community sexual health workshops where they perform a self-swab and receive a clinician swab in different sequences. The main outcomes are concordance of HPV results between the two collection methods and participants' acceptability and preferences. Results will show whether self-sampling delivered via community outreach can expand screening access in this population.
Why it matters
Potential benefit: If successful, self-swabbing could make HPV screening easier, more comfortable, and more accessible for vulnerable women, increasing early detection.
How similar studies have gone: Previous research has generally shown that self-collected HPV swabs can be similarly accurate and are often preferred by patients, so this approach has supporting evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 30 to 65, * In a vulnerable situation (beneficiary of a state or departmental social service, or referred by a charity), * Resident in one of the two municipalities targeted by the study, * Supported by the social services of one of the two municipalities targeted by the study, * Having agreed to participate in sexual health awareness meetings organized on site Exclusion Criteria: * Refusing to participate in the study * Having had a hysterectomy
Where it's running
-
Cegidd Saint Paul
Saint-Paul, France Recruiting -
CegiDD Saint Pierre
Saint-Pierre, France Recruiting
Study contacts
- Study coordinator: Emmanuelle THORE, dr
- Email: direction@chor.re
- Phone: +262 262 74 23 80
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.