Self-swab versus clinician-collected HPV screening for vulnerable women in Reunion
Concordance and Acceptability of Self-screening Compared to Screening Carried Out by a Health Professional for HPV, a Risk Factor for Anal Cancer, by Swab in People Living With HIV. A Randomized Controlled Crossover Study
This study tests whether self-collected swabs work as well and feel as acceptable as clinician-collected swabs for HPV screening in vulnerable women aged 30–65.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 300 (estimated) |
| Ages | 30 Years to 65 Years |
| Sex | Female |
| Sponsor | Centre Hospitalier Universitaire de la Réunion Academic / other |
| Locations | 2 sites (Saint-Paul and 1 other locations) |
| Trial ID | NCT07438080 on ClinicalTrials.gov |
What this trial studies
This randomized crossover study compares self-collected swabs to swabs taken by a health professional for HPV detection among vulnerable women living in two municipalities of Réunion. Participants are recruited through social services and attend community sexual health workshops where they perform a self-swab and receive a clinician swab in different sequences. The main outcomes are concordance of HPV results between the two collection methods and participants' acceptability and preferences. Results will show whether self-sampling delivered via community outreach can expand screening access in this population.
Who should consider this trial
Good fit: Ideal candidates are women aged 30–65 in vulnerable situations who live in one of the two targeted municipalities, are supported by local social services, and agree to attend the on-site sexual health meetings.
Not a fit: People who have had a hysterectomy, who do not live in the targeted municipalities, or who refuse participation are unlikely to benefit from this study's procedures.
Why it matters
Potential benefit: If successful, self-swabbing could make HPV screening easier, more comfortable, and more accessible for vulnerable women, increasing early detection.
How similar studies have performed: Previous research has generally shown that self-collected HPV swabs can be similarly accurate and are often preferred by patients, so this approach has supporting evidence.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 30 to 65, * In a vulnerable situation (beneficiary of a state or departmental social service, or referred by a charity), * Resident in one of the two municipalities targeted by the study, * Supported by the social services of one of the two municipalities targeted by the study, * Having agreed to participate in sexual health awareness meetings organized on site Exclusion Criteria: * Refusing to participate in the study * Having had a hysterectomy
Where this trial is running
Saint-Paul and 1 other locations
- Cegidd Saint Paul — Saint-Paul, France (Recruiting)
- CegiDD Saint Pierre — Saint-Pierre, France (Recruiting)
Study contacts
- Study coordinator: Emmanuelle THORE, dr
- Email: direction@chor.re
- Phone: +262 262 74 23 80
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.