Condition

HFrEF - Heart Failure With Reduced Ejection Fraction clinical trials and research

• 9Clinical trials
• 7Countries

Newest HFrEF - Heart Failure With Reduced Ejection Fraction clinical trials

All recruiting trials (9)

• Guideline Adherence in HFrEF: See If Mirror Information Helps Doctors and Patients Follow GDMT

  This study tests whether showing doctors, or both doctors and patients, mirror information about how well guideline-directed medical therapy is being used in heart failure with reduced ejection fraction.

  Recruiting Erasmus Medical Center · Rotterdam · NCT07702760

• Eccentric Muscle Training in Cardiac Rehab for Heart Failure with Reduced Ejection Fraction

  This study tests eccentric overload and eccentric cycling as part of a cardiac rehabilitation program for people with HFrEF to see if they build more muscle strength and mass than traditional training.

  Recruiting University Hospital, Antwerp · Edegem · NCT07636343

• Impact of Barostim on heart function in adults with reduced ejection fraction

  This trial tests whether implanting and adjusting the Barostim device can improve heart function and exercise ability in adults with HFrEF already taking maximal guideline-directed therapies.

  Recruiting Columbia University · San Francisco, California and 6 other locations · NCT07335510

• Predicting who improves after phase II cardiac rehabilitation for reduced ejection fraction

  This project will test whether blood microRNA patterns together with non-invasive exercise measurements can predict which people with reduced ejection fraction heart failure will improve their peak oxygen uptake after a phase II cardiac rehab program.

  Recruiting Centre Hospitalier de Corbie · Corbie · NCT07164911

• Swedish heart and kidney failure pilot

  This trial will test whether the drug eplerenone is safe and feasible for people with heart failure with reduced ejection fraction who also have severe chronic kidney disease.

  Recruiting Phase 2 Karolinska Institutet · Stockholm · NCT07029503

• Exploring heart failure and diabetes interactions

  This study looks at how heart failure and diabetes affect the body differently by testing 600 people with various combinations of these conditions.

  Recruiting University of Leeds · Leeds, West Yorkshire · NCT06774014

• AI-based assessment of heart function using ECG wearable monitors

  This study tests if a new AI tool using a wearable heart monitor can accurately check heart function in people with heart failure compared to traditional heart scans.

  Recruiting at 8 sites Peerbridge Health, Inc · Orange, California and 7 other locations · NCT06699056

• Vsling for Heart Failure: A first look at repair of the ventricle

  This study tests the Vsling device in adults with reduced heart pumping function to see if it is feasible and safe when implanted for ventricular repair.

  Recruiting Cardiac Success · Krakow · NCT06002386

• Targeting SERCA2a to improve heart function in patients with heart failure

  This study is testing a new treatment that uses a virus to help improve heart function in people with heart failure by correcting how calcium is handled in heart cells.

  Recruiting at 5 sites Phase 1/2 Sardocor Corp. · San Diego, California and 4 other locations · NCT04703842

Related topics

Quick answers

How many HFrEF - Heart Failure With Reduced Ejection Fraction clinical trials are recruiting right now?

9, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (3 trials), Belgium (1 trial), France (1 trial), Sweden (1 trial), Netherlands (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →