Predicting who improves after phase II cardiac rehabilitation for reduced ejection fraction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, single-center cohort of 62 patients with heart failure with reduced ejection fraction (LVEF <40%) who will complete a phase II exercise-based cardiac rehabilitation program. Researchers will measure peak oxygen uptake (VO2peak), cardiac hemodynamics, cerebral and muscle oxygenation during cardiopulmonary exercise testing, and circulating microRNA levels before and after the program. Participants will also perform a force–velocity test to guide individualized resistance training. The study links physiological exercise responses to molecular markers to identify predictors of improvement in ΔVO2peak.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Heart failure with reduced ejection fraction \< 40%
* NYHA functional class ≥ II
* Clinically stable for at least 6 weeks
* On optimized medical therapy for at least 6 weeks
* Prescription for phase II cardiac rehabilitation
* BMI between 20-30 kg·m-²
* Physical activity level: sedentary or physically active but untrained
* Signed informed consent to participate in the study
* Affiliation to the French national health insurance system

Exclusion Criteria:

* Contraindication to regular adapted physical activity
* Uncontrolled arterial hypertension
* Secondary respiratory disease such as emphysema or chronic obstructive pulmonary disease (COPD)
* Secondary cardiovascular disease
* Individuals under legal protection or deprived of liberty
* Pregnant or breastfeeding women

Where it's running

• Hospital center of Corbie
  Corbie, France Recruiting

Study contacts

• Principal investigator: Francesco Orlando, MD — Centre Hospitalier de Corbie
• Study coordinator: Pierre-Marie Leprêtre, professor
• Email: pierre-marie.lepretre@univ-rouen.fr
• Phone: +33235148113

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.