Condition

HFpEF - Heart Failure With Preserved Ejection Fraction clinical trials and research

• 13Clinical trials
• 5Countries

Newest HFpEF - Heart Failure With Preserved Ejection Fraction clinical trials

All recruiting trials (13)

• Tamibarotene for HFpEF: see if this drug helps heart failure with preserved ejection fraction

  A 12-week trial tests whether tamibarotene can reduce NT-proBNP levels in adults with HFpEF compared with placebo.

  Recruiting Phase 2 Nagoya University · Nagoya, Aichi-ken and 3 other locations · NCT07855692

• High-intensity interval training guided by cardiopulmonary exercise testing for HFpEF

  This trial tests whether a personalized high-intensity interval training program, guided by CPET results, can help people with heart failure with preserved ejection fraction improve their fitness and symptoms.

  Recruiting Peking University Third Hospital · Beijing and 12 other locations · NCT07693049

• Finerenone in patients having TAVI with heart failure

  This study tests whether finerenone can help people with heart failure and preserved ejection fraction who are undergoing transcatheter aortic valve implantation.

  Recruiting Phase 3 Second Affiliated Hospital, Zhejiang University, School of Medicine · Bengbu, Anhui and 60 other locations · NCT07575672

• Tiny ultrasound bubbles as an alternative to catheters for measuring pressures inside the heart

  This will test whether injecting tiny ultrasound bubbles can estimate heart filling pressures in people who are having a cardiac catheterisation.

  Recruiting King's College London · London · NCT07416279

• Tailored exercise training for adults with HFpEF

  This program will test remote, personalized exercise and lifestyle plans to see if they help adults with HFpEF or at risk of it improve how much they can exercise and their muscle health.

  Recruiting Phase 2/3 University of Texas Southwestern Medical Center · Dallas, Texas · NCT07223242

• US benchmarking of heart and liver stiffness using shear wave ultrasound

  This project will test whether a new ultrasound device can measure heart and liver stiffness using shear wave velocity in people aged 60 or older with preserved or mildly reduced ejection fraction and left ventricular hypertrophy, with or without transthyretin amyloid cardiomyopathy, and in control subjects.

  Recruiting at 3 sites eMyosound SAS · Boston, Massachusetts and 2 other locations · NCT07215715

• Exploring heart failure and diabetes interactions

  This study looks at how heart failure and diabetes affect the body differently by testing 600 people with various combinations of these conditions.

  Recruiting University of Leeds · Leeds, West Yorkshire · NCT06774014

• Dapagliflozin treatment for adults with failing Fontan circulation

  This study is testing if dapagliflozin, a diabetes medication, can help adults with heart failure after the Fontan procedure feel better by looking at changes in their heart pressure during rest and exercise.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT06762964

• AI-based assessment of heart function using ECG wearable monitors

  This study tests if a new AI tool using a wearable heart monitor can accurately check heart function in people with heart failure compared to traditional heart scans.

  Recruiting at 8 sites Peerbridge Health, Inc · Orange, California and 7 other locations · NCT06699056

• Motivating Physical Activity in HFpEF with Gamification and Social Incentives

  This trial will test whether gamified programs with either social support or friendly competition help adults with HFpEF increase their daily physical activity.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT06670001

• Ablation plus home exercise for diastolic heart failure and atrial fibrillation

  This study tests whether adding a 12-week home-based, video-supervised endurance, strength and breathing program to ablation improves peak oxygen uptake in people with HFpEF and short‑persistent atrial fibrillation.

  Recruiting Technical University of Munich · Munich · NCT06650995

• Comparing catheter ablation and drug therapy for atrial fibrillation in heart failure patients

  This study is testing whether a heart procedure called catheter ablation works better than medication for people with atrial fibrillation and heart failure.

  Recruiting The First Affiliated Hospital with Nanjing Medical University · Nanjing · NCT06125925

• Promoting exercise in adults with heart failure with preserved ejection fraction

  This study is testing whether different types of exercise coaching can help adults with heart failure feel better and improve their physical health.

  Recruiting at 2 sites University of Nebraska · Detroit, Michigan and 2 other locations · NCT05784753

Related topics

Quick answers

How many HFpEF - Heart Failure With Preserved Ejection Fraction clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (6 trials), China (3 trials), United Kingdom (2 trials), Germany (1 trial), Japan (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 2/3: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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