Guideline Adherence in HFrEF: See If Mirror Information Helps Doctors and Patients Follow GDMT

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The IMPLEMENT HF study uses data from the national heart failure registry in the Netherlands to compare two approaches for GDMT adherence: physician-only feedback versus feedback provided to both physician and patient. It is a registry-based, observational investigation focusing on 1500 de novo HFrEF patients and their treatment plans over one year. The primary outcome is the level of GDMT prescription, with secondary goals including dosing levels and clinical events. The study builds on prior work suggesting feedback can improve guideline implementation in real-world care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Written informed consent
2. Age ≥18 years
3. Diagnosis of HFrEF according to ESC HF 2026 guidelines (EF \<50%)
4. Participant is willing to participate for 1 years of follow-up for standard of care at the outpatient clinic of the participating hospital and the local investigator follows the patients for the time frame of 1 years on reported endpoints.

Exclusion Criteria:

1. An expected life expectancy less than 1 year due to other comorbidities according to the treating physician
2. A major CV event (e.g. disabling stroke, open heart surgery) within 3 months of enrollment, if likely to interfere with GDMT titration or regular follow-up.
3. Advanced or Endstage Heart Failure stage in which advanced HF treatment with an LVAD or heart transplant is anticipated within 6 months after the baseline visit.

At enrollment the patient has an established diagnosis of heart failure with reduction ejection fraction.

Where it's running

• Erasmus University Medical Centre
  Rotterdam, Netherlands Recruiting

Study contacts

• Study coordinator: Fleur Wildenbeest
• Email: f.wildenbeest@erasmusmc.nl
• Phone: +31107040704

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.