Condition

Heart Failure, Systolic clinical trials and research

• 12Clinical trials
• 25Countries

Newest Heart Failure, Systolic clinical trials

All recruiting trials (12)

• LY3971297 in heart failure: safety and tolerability in HF with preserved and reduced ejection fraction

  This study tests how well LY3971297 is tolerated and what side effects occur in people with HFpEF or HFrEF.

  Recruiting Phase 1 Eli Lilly and Company · Detroit, Michigan and 11 other locations · NCT07547540

• Acetazolamide versus metolazone added to usual diuretics for acute decompensated heart failure

  This trial will test whether adding acetazolamide or metolazone to standard diuretics works better and is safer for adults hospitalized with acute decompensated heart failure.

  Recruiting University of Health Sciences Lahore · Chak Eighty-seven -Twelve Left, Punjab Province · NCT07199088

• Heart performance during steep head-down positioning for robotic pelvic surgery

  This test looks at how heart function changes during steep head-down tilt in people having robotic pelvic surgery, including those with and without systolic heart failure.

  Recruiting Karlstad Central Hospital · Karlstad, Värmland County · NCT06336746

• Paced heart rate acceleration for improving heart function

  This study is testing if a special heart pacing treatment that mimics exercise can help people with systolic heart failure feel better and improve their heart function compared to a fake treatment.

  Recruiting University of Iowa · Iowa City, Iowa · NCT06332391

• Evaluating different approaches to cardiac pacing in patients

  This study is testing different ways to place pacemakers in adults to see which methods work best and are safest for patients needing heart support.

  Recruiting at 31 sites University Hospital of Ferrara · Ferrara, FE and 30 other locations · NCT06324682

• Exploring the links between oral bacteria, muscle blood flow, and fitness levels

  This study is trying to see how oral bacteria and fitness levels affect blood flow to muscles in people.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT06009276

• Comparing Aortix Device to Diuretics for Acute Heart Failure

  This study is testing whether the Aortix device can help people with acute heart failure who aren't responding to diuretics feel better compared to standard treatment.

  Recruiting at 33 sites Procyrion · Phoenix, Arizona and 49 other locations · NCT05677100

• Transplanting heart tissue to aid recovery after heart surgery

  This study is testing if using small pieces of heart tissue from patients' own hearts during surgery can help them heal better and improve heart function after dealing with heart disease and heart failure.

  Recruiting Hospital District of Helsinki and Uusimaa · Helsinki, Uusimaa · NCT05632432

• Comparing heart surgery options for patients with severe coronary artery disease

  This study is testing which heart surgery option, either bypass surgery or a less invasive procedure, works better for people with severe coronary artery disease and weakened heart function.

  Recruiting at 40 sites Sunnybrook Health Sciences Centre · Los Angeles, California and 45 other locations · NCT05427370

• Investigating heart disease risk factors in psoriasis patients

  This study is trying to see if certain heart-related markers can help predict heart disease risk in people with psoriasis.

  Recruiting Herlev and Gentofte Hospital · Hellerup, Copenhagne · NCT04950218

• Targeting SERCA2a to improve heart function in patients with heart failure

  This study is testing a new treatment that uses a virus to help improve heart function in people with heart failure by correcting how calcium is handled in heart cells.

  Recruiting at 5 sites Phase 1/2 Sardocor Corp. · San Diego, California and 4 other locations · NCT04703842

• Imaging-guided CRT using MRI and CT to personalize device placement

  A randomized approach tests whether guiding the CRT lead placement with MRI and CT information can improve outcomes for people with systolic heart failure.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT03398369

Related topics

Quick answers

How many Heart Failure, Systolic clinical trials are recruiting right now?

12, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 25 countries. The most sites are in United States (7 trials), Italy (2 trials), Denmark (1 trial), Sweden (1 trial), Finland (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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