Exploring heart failure and diabetes interactions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the differences in pathophysiology between individuals with and without heart failure, focusing on those with and without diabetes mellitus. It will involve 600 participants categorized into various groups based on their heart failure and diabetes status. Participants will undergo special heart scans, exercise testing, blood tests, and may provide samples of fat and muscle tissue for comprehensive analysis. The goal is to create a well-phenotyped cohort that allows for detailed comparisons of metabolic and proteomic interactions between tissues.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \>18 years
* Ability to provide written informed consent
* Persons who are legally competent and mentally able to follow the instructions of the study staff

Exclusion Criteria:

* Anaemia Hb \<8 mg/dl
* Patients with acute infectious diseases (e.g. pneumonia)
* Patients with heart failure due to sepsis
* People with acute myocardial ischemia, which is manifested, for example, by angina pectoris or ECG changes under stress
* Patients with acute liver or kidney failure or severe COPD (FEV1\<1.0)
* Pregnant and breastfeeding women
* People who are institutionalized on official or court orders
* People who are dependent or employed by the sponsor or investigator
* Taking study medication (of an investigational drug) 30 days before the start of the study

Where it's running

• Leeds Teaching Hospitals NHS Trust
  Leeds, West Yorkshire, United Kingdom Recruiting

Study contacts

• Study coordinator: Klaus Witte, MD
• Email: k.k.witte@leeds.ac.uk
• Phone: 007768254073

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• AI-based assessment of heart function using ECG wearable monitors

  This study tests if a new AI tool using a wearable heart monitor can accurately check heart function in people with heart failure compared to traditional heart scans.

  Recruiting at 8 sites Peerbridge Health, Inc · Orange, California and 7 other locations · NCT06699056

• Using Apple Watch data to predict heart failure outcomes

  This study is testing if data from Apple Watches can help predict heart failure problems and the chances of needing to go back to the hospital for patients with heart failure.

  Recruiting University Medical Center Goettingen · Goettigen, Lower Saxony · NCT06819618

• Comparing two diabetes medications, empagliflozin and dapagliflozin

  This study is testing which diabetes medication, empagliflozin or dapagliflozin, works better for people with type 2 diabetes, chronic kidney disease, and heart failure.

  Recruiting at 12 sites Phase 4 Herlev and Gentofte Hospital · Copenhagen and 11 other locations · NCT06642272

• Comparing Aortix Device to Diuretics for Acute Heart Failure

  This study is testing whether the Aortix device can help people with acute heart failure who aren't responding to diuretics feel better compared to standard treatment.

  Recruiting at 33 sites Procyrion · Phoenix, Arizona and 49 other locations · NCT05677100

• Targeting SERCA2a to improve heart function in patients with heart failure

  This study is testing a new treatment that uses a virus to help improve heart function in people with heart failure by correcting how calcium is handled in heart cells.

  Recruiting at 5 sites Phase 1/2 Sardocor Corp. · San Diego, California and 4 other locations · NCT04703842

• Identifying risks of heart failure and cognitive decline in people with type 2 diabetes

  This study is trying to find out which adults with type 2 diabetes might be at risk for heart failure and memory problems so that they can get early help.

  Recruiting University Hospital, Lille · Lille · NCT04583800

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.