Investigating the role of heat shock factors in blood cancers
Official title: Role of heat shock transcription factors (HSFs) in hematological malignancies
Funded at Augusta University · NIH-11001951 · Data updated 2026-11-12
This study is looking at how certain proteins called heat shock transcription factors affect the growth of acute myeloid leukemia (AML) and other blood cancers, with the goal of finding better treatments that could help patients feel better and live longer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | January 15, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $462,585 |
| NIH project number | 5R01CA276933-03 |
| Project ID | NIH-11001951 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults diagnosed with acute myeloid leukemia or other related hematological malignancies.
✕Less likely to help
Patients with non-hematological cancers or those who do not have acute myeloid leukemia may not benefit from this research.
What this research studies
This research focuses on understanding how heat shock transcription factors (HSFs) influence the development and treatment of acute myeloid leukemia (AML) and other hematological malignancies. By exploring the mechanisms of leukemic cell adaptation and resistance to therapies, the study aims to identify new therapeutic strategies that could improve treatment outcomes for patients. The research involves preclinical studies to assess the role of HSFs in cancer cell behavior and their potential as targets for innovative treatments. Patients may benefit from advancements in immunotherapy and targeted therapies that arise from this work.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for acute myeloid leukemia, improving survival rates and quality of life for patients.
How similar studies have gone: Previous research has shown promise in targeting heat shock factors in cancer treatment, indicating potential for success in this area.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Mivechi, Nahid F — Augusta University
- Study coordinator: Mivechi, Nahid F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.