Investigating genetic mutations in aggressive blood cancers.
Official title: Mutational cooperativity in TET2-associated hematological malignancies.
Funded at Texas A&m University Health Science Ctr · NIH-11063983 · Data updated 2026-11-12
This study is looking at how certain gene changes might lead to peripheral T cell lymphoma, an aggressive blood cancer, using special mice that have similar genetic traits to help find new ways to treat the disease, which could ultimately help patients understand and manage their condition better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University Health Science Ctr NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | April 1, 2021 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $341,592 |
| NIH project number | 5R01CA240258-05 |
| Project ID | NIH-11063983 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with peripheral T cell lymphoma or those with a family history of blood cancers.
✕Less likely to help
Patients with other types of blood cancers that do not involve TET2 or RHOA mutations may not benefit from this research.
What this research studies
This research focuses on peripheral T cell lymphoma (PTCL), a type of aggressive blood cancer. It aims to understand how specific genetic mutations, particularly in the TET2 and RHOA genes, contribute to the development of this disease. By using genetically modified mouse models that mimic the genetic changes found in PTCL patients, the research seeks to uncover the underlying mechanisms of the cancer and identify potential new treatment strategies. Patients may benefit from insights gained about the disease's progression and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and better outcomes for patients with peripheral T cell lymphoma.
How similar studies have gone: Previous research has shown promising results in understanding the genetic basis of blood cancers, making this approach both relevant and potentially impactful.
Where this research is happening
-
Texas A&m University Health Science Ctr
College Station, United States Active
Researchers
- Principal investigator: Huang, Yun — Texas A&m University Health Science Ctr
- Study coordinator: Huang, Yun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.