Improving Stem Cell Transplants for Blood Cancers and Other Diseases
Optimizing Hematopoietic Stem Cell Transplantation For The Treatment Of Hematological Malignancies
This work aims to make stem cell transplants safer and more effective for people with blood cancers, autoimmune diseases, and other serious conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11228615 on NIH RePORTER |
What this research studies
This project focuses on overcoming major challenges in hematopoietic cell transplantation (HCT), a curative therapy for many serious diseases. Researchers are working to improve how healthy stem cells are collected for transplant or gene therapy, reduce the harsh side effects of current chemotherapy and radiation treatments, and better control complications like graft-versus-host disease. The team is also developing new strategies to prevent diseases from returning after a transplant. This effort builds on extensive experience, including work that has already led to new FDA-approved treatments.
Who could benefit from this research
Good fit: Patients with hematological malignancies, hemoglobinopathies, autoimmune diseases, or inherited metabolic disorders who are candidates for stem cell transplantation may be ideal.
Not a fit: Patients who are not candidates for stem cell transplantation or related gene therapies would likely not receive direct benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and less toxic stem cell transplant procedures, offering better outcomes and quality of life for patients.
How similar studies have performed: This research builds on a strong foundation, with previous work from the lead researcher contributing to FDA-approved treatments and multiple completed clinical trials.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Dipersio, John F. — Washington University
- Study coordinator: Dipersio, John F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.