Registry for Patients With and Without Heart Failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational registry aims to comprehensively examine clinical characteristics, proteomic, metabolomic, genomic, and imaging data to understand the development and progression of different types of heart failure. Patients aged 18 and older, both with and without heart failure, will be enrolled to evaluate distinct heart failure phenotypes and cardiomyopathies, including amyloidosis. The study will collect baseline and one-year follow-up data, including blood samples and clinical outcomes, to optimize precision medicine in heart failure treatment.

Why it matters

Who can join: the full rules

Inclusion criteria for patients with HF:

* 18 years and older
* History of clinical symptoms consistent with HF and at least one of the following supporting evidence of HF:

  * NT-proBNP \> 125 pg/mL
  * BNP \> 35 pg/mL
  * Capillary wedge pressure ≥ 15 mmHg on right heart catheterization or CI \<2.8 L/min/m2
  * LVEDP ≥ 15 mmHg
  * Radiographic evidence of pulmonary edema
  * Improvement in symptoms with diuretic initiation of increase
  * CPET evidence of cardiac etiology of symptoms

HFpEF: LVEF ≥ 50% HFrEF: LVEF \<50%

Exclusion criteria (for all patients, including both those with HFpEF and HFrEF):

\- End stage renal disease on dialysis

Where it's running

• Massachusetts General Hospital
  Boston, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: Hanna Gaggin, MD, MPH — Massachusetts General Hospital
• Study coordinator: Abbie Macher, BS
• Email: ajmacher@mgh.harvard.edu
• Phone: 617-643-6328

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.