Using advanced imaging techniques to improve diagnosis and understanding of heart failure with preserved ejection fraction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the cardiac features and risk factors associated with heart failure with preserved ejection fraction (HFpEF) using a combination of advanced imaging techniques, including cardiovascular magnetic resonance imaging, echocardiography, and nuclear medicine imaging. By leveraging large datasets and artificial intelligence, the study aims to enhance early diagnosis and understanding of the disease, which is often overlooked due to its nonspecific clinical presentation. The research focuses on identifying subclinical changes in cardiac structure and function that are critical for timely intervention. The findings could lead to improved management strategies for patients suffering from HFpEF.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* left ventricular ejection fraction (LVEF)≥50%；
* N-terminal pro-b type natriuretic peptide (NT-proBNP)\>220pg/ml or b type natriuretic peptide (BNP) \>80 pg/ml;
* symptoms and syndromes of heart failure;
* At least one criteria of cardiac structure (left ventricular hypertrophy, or left atrial enlargement) and function abnormalities (based on tissue doppler, color doppler).

Exclusion Criteria:

* Special types of cardiomyopathy, including hypertrophic cardiomyopathy, restricted cardiomyopathy, etc.
* Infarction, myocardial fibrosis caused by ischemic cardiomyopathy and acute coronary syndrome ;
* Severe arrhythmia;
* Severe primary cardiac valvular disease;
* Restrictive pericardial disease;
* Refuse to participate in the study.

Where it's running

• Fuwai Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Minjie Lu, PhD — Fuwai Hospital, National Center for Cardiovascular Diseases.
• Study coordinator: Minjie Lu, PhD
• Email: coolkan@163.com
• Phone: 86 10 88396941

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.