Condition
Migraine Disease clinical trials and research
As of November 12, 2026, Find a Trial lists 6 Migraine Disease clinical trials that are recruiting, at sites in 4 countries (most in United States (2), Italy (2), Egypt (1)). By phase: Phase 1 (1), Phase 4 (1), Phase 3 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 6Clinical trials
- 4Countries
Newest Migraine Disease clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Gepants for Acute Migraine in the Emergency Department | Phase 1 | Tampa, Florida | Recruiting | Jun 25, 2026 |
| PFO-Directed Therapy for Migraines: Closing the Hole or Using a Blood Thinner | Phase 3 | New York, New York | Recruiting | Jun 5, 2026 |
| Neuropsychological and cognitive profile in adults with migraine | — | Milan | Recruiting | Nov 18, 2025 |
| Oral caffeine to reduce pain during acute migraine attacks | Phase 4 | Cairo | Recruiting | Jun 15, 2025 |
| Comparing EEG indicators to assess mindfulness therapy for migraine relief | — | Milan | Recruiting | Apr 22, 2025 |
| Aerobic exercise to improve sensory, muscle, and psychosocial symptoms in women with migraine | — | Ribeirão Preto, São Paulo | Recruiting | Dec 4, 2024 |
All recruiting trials (6)
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Gepants for Acute Migraine in the Emergency Department
This study tests whether rimegepant or zavegepant given in the ED can relieve an acute migraine for adults.
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PFO-Directed Therapy for Migraines: Closing the Hole or Using a Blood Thinner
This study tests whether closing a patent foramen ovale (PFO) plus 24 weeks of prasugrel works better for long-term migraine relief than prasugrel alone in people whose migraines improve on blood-thinning therapy.
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Neuropsychological and cognitive profile in adults with migraine
This project will test how thinking skills and psychological factors (like anxiety, depression, worry, and coping) relate to migraine in adults who have had migraine for at least one year.
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Oral caffeine to reduce pain during acute migraine attacks
This test will see if a single 200 mg oral caffeine tablet taken during an acute migraine can reduce pain for adults with episodic or chronic migraine with or without aura.
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Comparing EEG indicators to assess mindfulness therapy for migraine relief
This study is testing if mindfulness therapy can help people with frequent migraines feel better by looking at brain activity and using wearable devices to track progress at home.
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Aerobic exercise to improve sensory, muscle, and psychosocial symptoms in women with migraine
This trial will test whether supervised aerobic exercise plus one pain neuroscience education session helps women aged 18–48 with migraine reduce disability and improve sensory, musculoskeletal, and psychosocial symptoms.
Related topics
Quick answers
How many Migraine Disease clinical trials are recruiting right now?
6, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 4 countries. The most sites are in United States (2 trials), Italy (2 trials), Egypt (1 trial), Brazil (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 1: 1, Phase 4: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.