Using Idebenone to prevent migraines

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of idebenone, a compound that enhances energy metabolism, in preventing episodic migraines. A total of 180 participants aged 18 to 65 will be randomly assigned to receive either idebenone at doses of 90 mg or 270 mg per day, or a placebo, in a double-blind manner. The study aims to determine if idebenone is superior to placebo in reducing the frequency of migraine attacks. Participants must meet specific criteria for episodic migraine and have not used other prophylactic treatments for at least three months prior to enrollment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Clinical diagnosis of episodic migraine.
2. Patients (18-65 years) were eligible if they met International Headache Society (IHS) criteria for episodic migraine with/ without aura with a migraine history 1 year
3. Two to eight attacks per month, 5 days/month of interval headaches.
4. No over consumption of acute anti-migraine medication.
5. No other prophylactic medication (washout 3 months).
6. No serious organic or psychiatric disease.
7. Only women with contraceptive protection.

Exclusion Criteria:

1. Clinical diagnosis of chronic migraine.
2. Subjects previously discontinued idebenone due to adverse events.
3. Subjects are taking idebenone or had taken idebenone within 14 days prior to enrollment.
4. Subjects with continuous headaches.

Where it's running

• Kaiming Liu
  Hangzhou, Zhejiang, China Recruiting

Study contacts

• Study coordinator: Kaiming Liu, MD & PHD
• Email: 2314411@zju.edu.cn
• Phone: +8615068862055

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.