Condition

MGMT-Unmethylated Glioblastoma clinical trials and research

• 6Clinical trials
• 2Countries

Newest MGMT-Unmethylated Glioblastoma clinical trials

All recruiting trials (6)

• Temporally-Modulated Pulsed Radiation Therapy plus TMZ for MGMT-Unmethylated Glioblastoma

  This study tests whether temporally-modulated pulsed radiation therapy plus temozolomide improves outcomes for people with newly diagnosed MGMT-unmethylated, IDH-wildtype glioblastoma.

  Recruiting at 54 sites Phase 3 NRG Oncology · Irvine, California and 53 other locations · NCT07452458

• Adding ruxolitinib to standard radiation and temozolomide for newly diagnosed glioblastoma

  This trial will try whether adding the oral drug ruxolitinib to standard radiation and temozolomide helps adults newly diagnosed with glioblastoma.

  Recruiting at 2 sites Phase 2 Baptist Health South Florida · Miami, Florida and 1 other locations · NCT06991101

• Combination of DB107-RRV, DB107-FC, and radiation therapy for high grade glioma

  This study is testing a new combination of treatments for people with newly diagnosed high grade glioma to see if it helps them live longer without their cancer getting worse after surgery.

  Recruiting at 5 sites Phase 1/2 University of California, San Francisco · Los Angeles, California and 4 other locations · NCT06504381

• E-SYNC CAR T cell therapy for EGFRvIII positive glioblastoma

  This study is testing a new type of CAR T cell therapy to see if it can help people with a specific type of brain cancer called EGFRvIII positive glioblastoma after they have had chemotherapy.

  Recruiting Phase 1 University of California, San Francisco · San Francisco, California · NCT06186401

• Using crizanlizumab alone or with nivolumab for treating advanced glioblastoma and melanoma with brain metastases

  This study is testing if a new treatment called crizanlizumab, alone or with another drug called nivolumab, can help people with advanced brain cancer from glioblastoma or melanoma that has spread to the brain.

  Recruiting Phase 2 Sheba Medical Center · Ramat Gan, Israel · NCT05909618

• Combining WP1066 with radiation therapy for newly diagnosed glioblastoma

  This study is testing if adding a new drug called WP1066 to regular radiation therapy can help people with newly diagnosed glioblastoma live longer and feel better.

  Recruiting Phase 2 Northwestern University · Chicago, Illinois and 1 other locations · NCT05879250

Related topics

Quick answers

How many MGMT-Unmethylated Glioblastoma clinical trials are recruiting right now?

6, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (5 trials), Israel (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1: 1, Phase 3: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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