Understanding the genetic causes of testicular germ cell tumors in children and adults
Official title: Mechanisms and Fetal Origins Underlying Gonadal Germ Cell Tumor-AWARDED
Funded at Children's Research Institute · NIH-10926818 · Data updated 2026-11-12
This study is looking at how certain genes might play a role in testicular cancer, especially in young men and boys with unique genital conditions, to help find better ways to prevent and treat this type of cancer in the future.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Research Institute NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | May 14, 2022 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $216,761 |
| NIH project number | 5K08CA248704-05 |
| Project ID | NIH-10926818 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children and young adults with gonadal/genital atypia or a family history of testicular germ cell tumors.
✕Less likely to help
Patients without gonadal/genital atypia or those who do not have a family history of testicular germ cell tumors may not benefit from this research.
What this research studies
This research investigates the genetic factors that contribute to testicular germ cell tumors (TGCT), which are the most common cancer in men aged 15-45 and pose a significant risk to children with gonadal/genital atypia. The study aims to identify specific genes and mechanisms that lead to these tumors by utilizing innovative modeling techniques with induced pluripotent stem cells and analyzing a large genetic biobank of children. By understanding how certain genetic variations affect germ cell development, the research seeks to inform future precision medicine approaches for prevention and treatment of TGCT.
Why it matters
Potential benefit: If successful, this research could lead to targeted prevention and treatment strategies for individuals at risk of developing testicular germ cell tumors.
How similar studies have gone: Previous research has successfully identified genetic predispositions for other cancers, suggesting that this approach may yield valuable insights into TGCT as well.
Where this research is happening
-
Children's Research Institute
Washington, United States Active
Researchers
- Principal investigator: Pyle, Louise Clare — Children's Research Institute
- Study coordinator: Pyle, Louise Clare
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.