Condition

Adenoid Cystic Carcinoma clinical trials and research

• 17Clinical trials
• 6NIH research projects
• 5Countries

Newest Adenoid Cystic Carcinoma clinical trials

All recruiting trials (17)

• Docetaxel and SX-682 in head and neck cancers and prostate cancer

  This trial tests a new drug SX-682 together with docetaxel in adults whose head and neck cancers or prostate cancer have returned or spread.

  Recruiting Phase 1/2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07667400

• Surgery Plus Postoperative Radiotherapy for T4 Sinonasal Adenoid Cystic Carcinoma

  This study tests how well patients with T4 sinonasal adenoid cystic carcinoma tolerate the standard treatment of surgery followed by postoperative radiotherapy and what their 3-year progression-free survival looks like.

  Recruiting Eye & ENT Hospital of Fudan University · Harbin, Heilongjiang and 5 other locations · NCT07652489

• Neoadjuvant therapy with anlotinib and epirubicin for T4 sinonasal adenoid cystic carcinoma

  This trial tests whether giving a targeted drug (anlotinib) plus chemotherapy (epirubicin) before surgery helps patients with advanced sinonasal adenoid cystic carcinoma see better outcomes.

  Recruiting Phase 2 Eye & ENT Hospital of Fudan University · Beijing, Beijing Municipality and 4 other locations · NCT07616141

• Surgery Alone or with Postoperative Radiotherapy for Sinonasal Adenoid Cystic Carcinoma

  This study tests whether watching closely after surgery is as safe as adding postoperative radiotherapy for adults with completely removed (R0) early-stage sinonasal adenoid cystic carcinoma.

  Recruiting Eye & ENT Hospital of Fudan University · Shanghai · NCT07563088

• Becotatug vedotin plus epirubicin before surgery for EGFR-positive unresectable recurrent sinonasal adenoid cystic carcinoma

  This will test whether combining becotatug vedotin with epirubicin can shrink EGFR-positive, unresectable recurrent sinonasal adenoid cystic carcinoma enough to allow surgery or improve disease control.

  Recruiting Phase 2 Eye & ENT Hospital of Fudan University · Shanghai · NCT07522879

• Epirubicin chemoembolization to shrink sinonasal adenoid cystic carcinoma

  This treatment tries three sessions of targeted transarterial Epirubicin chemoembolization in people with locally advanced sinonasal adenoid cystic carcinoma to shrink tumors and decide if surgery can be avoided.

  Recruiting Phase 2 Eye & ENT Hospital of Fudan University · Shanghai, Xuhui Strict · NCT07320508

• Puxitatug Samrotecan (P‑Sam) for advanced, recurrent, or metastatic aggressive ACC‑I

  This test sees if Puxitatug Samrotecan (P‑Sam) can shrink tumors or slow disease in adults with aggressive, recurrent, or metastatic ACC‑I, especially tumors with NOTCH mutations or low p63 expression.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT07162480

• Testing Enfortumab Vedotin for Adenoid Cystic Carcinoma

  This study is testing if a new drug called enfortumab vedotin can help people with advanced adenoid cystic carcinoma feel better when other treatments aren't an option.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT06891560

• Testing a new drug for advanced solid tumors that express c-Kit

  This study is testing a new drug for people with advanced solid tumors that have a specific marker called c-Kit to see if it is safe and how well it works.

  Recruiting at 4 sites Phase 1 Novelty Nobility, Inc. · Ann Arbor, Michigan and 4 other locations · NCT06805825

• Evaluating Ivonescimab for advanced salivary gland cancers

  This study is testing a new treatment called Ivonescimab to see if it can help people with advanced salivary gland cancers feel better and improve their health.

  Recruiting at 2 sites Phase 2 Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT06805617

• Evaluating HG146 for patients with adenoid cystic carcinoma

  This study is testing a new treatment called HG146 to see if it can help people with recurrent or metastatic adenoid cystic carcinoma feel better and manage their disease.

  Recruiting Phase 2 HitGen Inc. · Shanghai, Shanghai Municipality · NCT06781567

• Treatment of advanced Adenoid Cystic Carcinoma with REM-422

  This study is testing a new oral medication called REM-422 to see if it can safely shrink tumors in people with advanced Adenoid Cystic Carcinoma that keeps coming back or has spread.

  Recruiting at 9 sites Phase 1/2 Remix Therapeutics · San Francisco, California and 8 other locations · NCT06118086

• CB-103 combined with lenvatinib or abemaciclib for NOTCH-activated adenoid cystic carcinoma

  This study tests whether combining the NOTCH inhibitor CB-103 with either lenvatinib or abemaciclib can slow tumor growth in adults with NOTCH-activated advanced or metastatic adenoid cystic carcinoma.

  Recruiting Phase 1/2 Dana-Farber Cancer Institute · Boston, Massachusetts · NCT05774899

• Testing a new drug called XMT-1660 for solid tumors

  This study is testing a new drug called XMT-1660 to see if it is safe and effective for people with hard-to-treat solid tumors like triple negative breast cancer and ovarian cancer.

  Recruiting at 26 sites Phase 1/2 Day One Biopharmaceuticals, Inc. · Phoenix, Arizona and 25 other locations · NCT05377996

• Early treatment of metastatic adenoid cystic carcinoma with focused radiation therapy

  This study is testing if starting focused radiation therapy early can help people with a specific type of cancer that has spread to a few places feel better and live longer compared to standard treatment.

  Recruiting at 5 sites Dana-Farber Cancer Institute · San Francisco, California and 4 other locations · NCT04883671

• Carbon ion irradiation for adenoid cystic carcinoma

  This study is testing if carbon ion therapy can be a more effective and quicker treatment for people with adenoid cystic carcinoma, a rare type of head and neck tumor.

  Recruiting Phase 2 Heidelberg University · Heidelberg · NCT04214366

• Treatment of solid tumors or lymphoma with VMD-928

  This study is testing a new oral medication called VMD-928 to see if it can help adults with advanced solid tumors or lymphoma that haven't improved with standard treatments.

  Recruiting at 13 sites Phase 1/2 VM Oncology, LLC · Santa Rosa, California and 12 other locations · NCT03556228

NIH-funded research (6)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Exploring understudied proteins as potential drug targets for adenoid cystic carcinoma

  A small NIH grant is funding a patient-focused look at rare salivary gland cancer to find new proteins that could become targeted treatments.

  NIH research University of Chicago · Chicago, United States · NIH-11453523

• DNA methylation clues to predict and guide ACC treatment

  This project looks at DNA methylation patterns in adenoid cystic carcinoma (ACC) to find markers that predict how aggressive the cancer will be and how patients might respond to therapy.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11385408

• Salivary gland cancer: how nerves may drive growth and how to stop it

  Aims to understand how nerve signals help adenoid cystic carcinoma grow and test therapies that could interrupt those signals to help patients.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11344524

• Genetic changes and target genes in adenoid cystic carcinoma

  Researchers are analyzing genetic changes in adenoid cystic carcinoma tumors to find gene targets that could lead to better tests and treatments for people with ACC.

  NIH research University of New Mexico Health Scis Ctr · Albuquerque, United States · NIH-11294168

• Using tumor and blood DNA methylation to predict outcomes and guide treatment for adenoid cystic carcinoma

  This project looks at DNA methylation patterns in tumor tissue and blood to help predict how adenoid cystic carcinoma will behave and to guide treatment choices for people with ACC.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11144479

• Using DNA Methylation to Improve Treatment for Salivary Gland Cancer

  This study is looking at how changes in DNA can help doctors understand different types of adenoid cystic carcinoma, a kind of salivary gland cancer, by checking tumor samples and blood from patients to find clues that could improve treatment and track how the disease is doing.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-10941953

Related topics

Quick answers

How many Adenoid Cystic Carcinoma clinical trials are recruiting right now?

17, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (10 trials), China (6 trials), Puerto Rico (1 trial), France (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 8, Phase 1/2: 5, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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