Evaluating Avapritinib for Advanced Gastrointestinal Stromal Tumors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter observational study aims to assess the efficacy and safety of Avapritinib in patients with metastatic or unresectable gastrointestinal stromal tumors (GISTs). It will analyze therapy patterns and clinical outcomes in real-world settings, focusing on patients who have confirmed GISTs and are treated with Avapritinib. The study will include patients aged 18 and older with measurable lesions and an ECOG performance status of 0 to 2. By gathering data from multiple centers, the study seeks to provide insights into the effectiveness of this targeted therapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients who are aged ≥ 18 years.
* Gastrointestinal stromal tumors confirmed by histopathological examination, and CD- and/or DOG-1-positive by immunohistochemistry.
* Presence of mRECIST v1.1-compliant lesions with at least one measurable lesion (non-lymphadenopathy ≥1.0 cm or ≥2-fold scan slice thickness).
* Treatment with Avapritinib.
* Patients with an Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0 to 2 at screening.
* Patient informed consent and signed written consent form.
* The patient was compliant and voluntarily scheduled for follow-up, treatment, laboratory tests, and other study procedures.

Exclusion Criteria:

* KIT or PDGFRA wild type.
* Failure to complete continuous atorvastatin for at least 15 days due to intolerability or disease progression.
* Other serious acute or chronic physical or mental problems, or laboratory abnormalities, may increase the risk associated with participation in the study or use of drugs, or interfere with the judgment of the study results and, in the judgment of the investigator, are not considered appropriate for participation in the investigator.

Where it's running

• The First Affiliated Hospital, Sun Yat-sen University
  Guangzhou, China Recruiting

Study contacts

• Principal investigator: Xinhua Zhang, PhD — First affiliated hosptial,Sun Yat-sen university
• Study coordinator: Xinhua Zhang, PhD
• Email: zhangxinhua@mail.sysu.edu.cn
• Phone: +8620-87332200

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.